Sökning: "dorsal horn"

Visar resultat 31 - 35 av 47 avhandlingar innehållade orden dorsal horn.

  1. 31. Deciphering neural networks in the somatosensory system using single-cell transcriptomics and rabies tracing

    Författare :Jon E. T. Jakobsson; Malin C. Lagerström; Victoria Abraira; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; neural networks; somatosensory system; itch; rabies tracing; scRNA-seq;

    Sammanfattning : Itch has evolved to protect us from malicious parasites keen to suck our blood or lay their eggs in our skin. We can detect both the movement of these parasites and the toxins they introduce with specialized neurons called pruriceptors. When we feel an itch, we get a desire to scratch it. LÄS MER

  3. 32. Calcium-binding proteins as markers and functional determinants of neurons in pain networks

    Författare :Mingdong Zhang; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The thesis focuses on the anatomical and cellular distribution of three EF-hand calcium binding proteins, secretagogin, neuronal calcium-binding protein 1 (NECAB1) and NECAB2 in dorsal root ganglia (DRGs) and spinal cord of three species, mouse, rat and human, and their possible roles in pathophysiological pain. In Paper I and Paper IV, we report that the expression of secretagogin is limited to a small subpopulation of peptidergic neurons in mouse and human DRGs expressing calcitonin generelated peptide (CGRP). LÄS MER

  4. 33. Insights into the role of spinal mTOR in the modulation of inflammation and nociception

    Författare :Ebba Gregory; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Pain, especially chronic pain, is a major clinical problem. Pain therapy has proven to be complicated and the results are often unsatisfactory. Despite many years of research, the number of available pain therapeutics remains relatively small. LÄS MER

  5. 34. Peptidergic projections from the rat paraventricular hypothalamic nucleus to the spinal cord

    Författare :Martin Hallbeck; Arthur Loewy; Linköpings universitet; []
    Nyckelord :MEDICINE; MEDICIN;

    Sammanfattning : The survival of the organism is dependent on keeping a balanced internal milieu in an ever-changing environment The process to achieve this balance is called homeostasis and it is accomplished by the consonant action of the endocrine system and the autonomic nervous system. Specific parts of the central nervous system (CNS) control these systems in response to various sensory inputs. LÄS MER

  7. 35. Neuroprotection in the Injured Spinal Cord : Novel Strategies using Immunomodulation, Stem cell Transplantation and Hyaluronic acid Hydrogel carriers

    Författare :Nikos Schizas; Nils Hailer; Elena Kozlova; Mikael Svensson; Uppsala universitet; []
    Nyckelord :Hyaluronic Acid-based hydrogel; motorneurons; microglial cells; Interleukin-1 Receptor Antagonist; Renshaw cells; excitotoxicity; neuroinflammation; Neural Crest Stem Cells; Medicinsk vetenskap; Medical Science;

    Sammanfattning : The overall aim of this thesis was to establish strategies to minimize secondary damage to the injured spinal cord. Secondary damage that follows spinal cord injury (SCI) involves inflammatory and excitotoxic pathways. LÄS MER