Sökning: "cytochrome P450"

Visar resultat 31 - 35 av 151 avhandlingar innehållade orden cytochrome P450.

  1. 31. Cytochrome P450 enzymes in oxygenation of prostaglandin endoperoxides and arachidonic acid : Cloning, expression and catalytic properties of CYP4F8 and CYP4F21

    Författare :Johan Bylund; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutical biosciences; Farmaceutisk biovetenskap; Biopharmacy; Biofarmaci; farmaceutisk biokemi; Pharmaceutical Biochemistry;

    Sammanfattning : Cytochrome P450 (P450 or CYP) is an enzyme system involved in the oxygenation of a wide range of endogenous compounds as well as foreign chemicals and drugs. This thesis describes investigations of P450-catalyzed oxygenation of prostaglandins, linoleic and arachidoniacids. LÄS MER

  3. 32. Characteristics of cytochrome P450-catalysed drug metabolism with focus on a black Tanzanian population

    Författare :Agneta Wennerholm; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Drug metabolism; cytochrome P450; polymorphism; pharmacogenetics; genotyping; phenotyping; CYP2D6; CYP3A; debrisoquine; amodiaquine; alprazolam;

    Sammanfattning : The cytochrome P450 (CYP) enzymes display interindividual and interethnic variability that may alter the disposition of substances metabolised by these enzymes. Both genetic and environmental factors such as concomitant drug use and concurrent diseases influence the activities of these enzymes. LÄS MER

  4. 33. Cytochrome P450 2C9 polymorphism : interindividual differences in drug metabolism and phenotyping methodology

    Författare :Umit Yasar; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :CYP2C9 polymorphism; phenotyping; genotyping; diclofenac; losartan;

    Sammanfattning : Cytochrome P450 2C9 (CYP2C9) is one of the most important drug metabolizing enzymes in human liver. It catalyses the metabolism of a wide range of different drugs such as S-warfarin, acenocoumarol, losartan, irbesartan, phenytoin, sulphamethoxazole, tolbutamide, glipizide and numerous non-steroidal antiinflammatory drugs. LÄS MER

  5. 34. Interindividual variation in drug metabolism with focus on polymorphic cytochrome P450 2C9

    Författare :Mia Sandberg Lundblad; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Cytochromes P450 (CYP) are enzymes, mainly catalysing the oxidation of xenobiotics, in order to facilitate their excretion from the body. CYP2C9 is a polymorphic enzyme, which is responsible for the metabolism of about 10 % of all known drugs, e. LÄS MER

  7. 35. Molecular basis and structural determinants for the cellular localization of cytochrome P450 2E1

    Författare :Etienne P A Neve; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Cytochrome P450 2E1 (CYP2E1) is the alcohol inducible member of the P450 family and has a role in gluconeogenesis under fasting conditions. However, CYP2E1 is mainly of toxicological significance and metabolizes xenobiotics to their carcinogenic and toxic metabolites and generates active oxygen species that can cause lipid peroxidation and apoptosis, processes observed in alcoholic liver disease (ALD). LÄS MER