Sökning: "cytochrome P450"

Visar resultat 11 - 15 av 151 avhandlingar innehållade orden cytochrome P450.

1. 11. Cytochrome P450 2E1 - relevance for central dopamine neurotransmission and Parkinson's disease

   Författare :Haydeh Niazi Shahabi; Göteborgs universitet; []
   Nyckelord :cytochrome P450 2E1; dopamine; substantia nigra; polymorphism; alternative splicing;

   Sammanfattning : Introduction: The enzyme cytochrome P450 2E1 (CYP2E1) has been found in dopamine (DA) containing brain regions that are of relevance for Parkinson?s disease (PD), and is known to generate reactive oxygen species (ROS), toxic molecules that have been implicated in the degeneration of DA neurones. In addition, previous investigations have indicated that inhibition of CYP2E1 increases extracellular DA in the substantia nigra, a nucleus which degenerates in PD. LÄS MER

3. 12. Qualitative and Quantitative Assessment of Cytochromes P450 mRNA in Human : Studies in the Liver, Blood and Gastrointestinal Mucosa

   Författare :Mari Thörn; Lars Lööf; Anders Rane; Ellen Vinge; Uppsala universitet; []
   Nyckelord :Medical sciences; cytochrome P450; CYP1A2; CYP1B1; CYP2E1; CYP3A4; CYP3A5; P-gp; gene expression; RT-PCR; liver; blood; gastrointestinal mucosa; MEDICIN OCH VÅRD; MEDICINE; MEDICIN;

   Sammanfattning : Drugs and other foreign compounds must often be metabolised before they can be excreted from the body. One enzyme system that is responsible for this is the cytochrome P450 gene family (CYP). LÄS MER

4. 13. Toxicological and endocrinolgical aspects of cytochrome P450 in breast and lung

   Författare :Heike Hellmold; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :cytochrome P450; breast; lung; metabolism;

   Sammanfattning : Cytochrome P450 (CYP) enzymes have well characterized functions in disposition and pharmacokinetics of xenobiotics as well as in biosynthesis and/or metabolism of endogenous compounds, such as steroid hormones, bile acids, arachidonic acid and its derivatives. Cytochrome P450 mediated metabolic activation is known to be a prerequisite for the cytotoxic and mutagenic activity of many environmental toxins and procarcinogens. LÄS MER

5. 14. Pharmacogenetics of human cytochrome P450 3A (CYP3A) enzymes

   Författare :Anna Westlind Johnsson; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : The cytochrome P450 3A (CYP3A) subfamily encompasses the most important CYP enzymes with respect to drug metabolism, in particular CYP3A4. responsible for the metabolism of a majority of drugs being metabolized in order to be excreted. LÄS MER

7. 15. Genetic polymorphism and regulation of cytochrome P450 2E1

   Författare :Yin Hu; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Cytochrome P450 2E1 (CYP2E1) participates in the metabolism of several xenobiotics. A physiological role of CYP2E1 is its ability to convert acetone into gluconeogenetic precursors. Due to a pronounced oxidase activity CYP2E1 can generate substantial amount of oxygen free radicals and may contribute to oxidative stress. LÄS MER