Sökning: "genetic subtypes"

Visar resultat 1 - 5 av 172 avhandlingar innehållade orden genetic subtypes.

  1. 1. Significance of HIV-1 genetic subtypes

    Författare :Annette Alaeus; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :HIV-1; genetic subtypes; molecular epidemiology; disease progression; CD4 cell decline; plasma RNA levels; chemokine coreceptor usage;

    Sammanfattning : The human immunodeficiency virus type 1 (HIV-1) displays high genetic variability. Phylogenetic studies have shown that a majority of HIV-1 sequences cluster into one large group called M (major), whereas a few are clearly distinct, group O (outlier) and group N (non-M-non-O). LÄS MER

  3. 2. Genetic association studies in stroke

    Författare :Claes Ladenvall; Göteborgs universitet; []
    Nyckelord :stroke; ischemic stroke subtypes; subarachnoid hemorrhage; genetics; polymorphism; fibrinolysis; tPA; PAI-1; TAFI; CRP; Factor XIII;

    Sammanfattning : Stroke is the third most common cause of death and the most common cause of disability in adults in developed countries. It is a complex disease in which genetic and environmental factors make about equal contributions. LÄS MER

  4. 3. Genetics of diabetic subtypes

    Författare :Camilla Cervin; Diabetes - klinisk obesitasforskning; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Endocrinology; secreting systems; diabetology; Endokrinologi; Mutation; Association; Genetics; LADA; Diabetes; MODY; sekretion; diabetologi;

    Sammanfattning : There are two major types of diabetes mellitus, Type 1 Diabetes (T1D) and Type 2 Diabetes (T2D), however a number of subtypes have been defined and classified. Maternally Inherited Diabetes and Deafness (MIDD) and Maturity Onset Diabetes of the Young (MODY) are monogenic forms, whereas Latent Autoimmune Diabetes in Adults (LADA) is thought to be a polygenic subtype similar to T1D. LÄS MER

  5. 4. Genetics of Diabetes Subtypes. Characterization of novel cluster-based diabetes subtypes

    Författare :Dina Mansour Aly; diabetes och endokrinologi Genomik; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Precision medicine; Diabetes Subclassification; genome-wide association studies; GWAS; genetic risk scores; GRS; chronic kidney disease; CKD; diabetic kidney disease; DKD; Estimated glomerular filtration rate; eGFR; ANDIS; diabetes; diabetics;

    Sammanfattning : BACKGROUND: Type 2 diabetes (T2D) has been reproducibly clustered into five subtypes based on six-clinical variables; age at diabetes onset, body mass index (BMI), Glutamic acid decarboxylase autoantibodies (GADA), glycated hemoglobin (HbA1c) and insulin secretion and resistance estimated as HOMA2B and HOMA2IR derived from fasting glucose and Cpeptide. These subtypes have different disease progression and risk of complications. LÄS MER

  7. 5. Genetic and Epigenetic Characterisation of Breast Tumours

    Författare :Karolina Holm; Bröstcancer-genetik; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Breast cancer; PIK3CA; PTEN; PI3K pathway; CCND1; microarrays; molecular subtypes; DNA methylation; EZH2; H3K27me3; PRC2; histone modification;

    Sammanfattning : Breast tumours harbour a large amount of genetic and epigenetic alterations, which are associated with e.g. tumour aggressiveness, prognosis, and response to therapy. LÄS MER