Sökning: "computational mass spectrometry"

Visar resultat 1 - 5 av 24 avhandlingar innehållade orden computational mass spectrometry.

  1. 1. Novel strategies to increase throughput and differentiate lipid isomers in mass spectrometry imaging : Development of computational tools and complex mass spectrometric methods for nanospray desorption electrospray ionization

    Författare :Johan Lillja; Ingela Lanekoff; Daniel Globisch; Orešič Matej; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Mass spectrometry; Mass spectrometry imaging; Tandem mass spectrometry; Silver cationization; Mathematical modeling; Lipid; Lipid isomer; Kemi med inriktning mot analytisk kemi; Chemistry with specialization in Analytical Chemistry;

    Sammanfattning : In this thesis, method development for improved analyte identification and throughput in mass spectrometry imaging (MSI) is discussed. In MSI, the spatial distribution of analytes from a sample is determined and visualized, information about the detected molecules interaction within the sample can thereby the deduced. LÄS MER

  3. 2. Quantitative analysis of mass spectrometry proteomics data : Software for improved life science

    Författare :Johan Teleman; Institutionen för immunteknologi; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; computational proteomics; bioinformatics; life science; data complexity; algorithms; mass spectrometry;

    Sammanfattning : The rapid advances in life science, including the sequencing of the human genome and numerous other techiques, has given an extraordinary ability to aquire data on biological systems and human disease. Even so, drug development costs are higher than ever, while the rate of new approved treatments is historically low. LÄS MER

  4. 3. The accuracy of statistical confidence estimates in shotgun proteomics

    Författare :Viktor Granholm; Lukas Käll; Alexey Nesvizhskii; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Proteomics; Peptides; Statistics; Mass spectrometry; Tandem mass spectrometry; Biochemistry towards Bioinformatics; biokemi med inriktning mot bioinformatik;

    Sammanfattning : High-throughput techniques are currently some of the most promising methods to study molecular biology, with the potential to improve medicine and enable new biological applications. In proteomics, the large scale study of proteins, the leading method is mass spectrometry. LÄS MER

  5. 4. Development of Computational Methods for Cancer Research: Strategies for closing the feedback loop in omics workflows

    Författare :Ufuk Kirik; Institutionen för immunteknologi; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; cancer; proteome profiling; bioinformatics; pathway analysis; mass spectrometry; Quantitative proteomics;

    Sammanfattning : As the ultimate workhorses of the living things, proteins undergo significant regulatory activity throughout the lifetime of a cell or an organism. Many complex diseases effect the protein composition, expression or modification in the cells or tissues they arise in. LÄS MER

  7. 5. Chromatographic retention time prediction and its applications in mass spectrometry-based proteomics

    Författare :Luminita Moruz; Lukas Käll; Arne Elofsson; Benno Schwikowski; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; mass spectrometry; reversed-phase liquid chromatography; retention time prediction; bioinfomatics; computational mass spectrometry; Biochemistry towards Bioinformatics; biokemi med inriktning mot bioinformatik;

    Sammanfattning : Mass spectrometry-based methods are among the most commonly used techniques to characterize proteins in biological samples. With rapid technological developments allowing increasing throughput, thousands of proteins can now be monitored in a matter of hours. However, these advances brought a whole new set of analytical challenges. LÄS MER