Sökning: "coculture"

Visar resultat 11 - 15 av 16 avhandlingar innehållade ordet coculture.

  1. 11. Notch receptor processing and CNS disease

    Författare :Helena Karlström; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : We have studied the relationship of Notch receptor processing and two diseases of the central nervous system: Alzheimer's disease (AD) and Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL). The Notch receptor signalling pathway plays a crucial role during development in many different species for directing adjacent cells to adopt different fates. LÄS MER

  3. 12. Mesenchymal stem cells in vascular structure and remodeling in cancer

    Författare :Ewa Kurzejamska; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Mesenchymal stem cells (MSCs) are present in vascular structure and play an important role in vessel remodeling in normal, as well as pathological conditions, such as transplant arteriosclerosis or tumor angiogenesis. Moreover, MSCs affect tumor growth and metastasis by production of chemokines, such as (C-C motif) ligand 7 (CCL7). LÄS MER

  4. 13. Glucocorticoids in the development and homeostasis of T lymphocytes

    Författare :Ahmad Pazirandeh; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Until recently the fact that glucocorticoids (GCs) play an essential physiological role in regulation of the immune system in health and disease was not fully appreciated. The main aims of this thesis were to investigate the effects of physiological nonstressed levels of endogenous GCs on the development, differentiation and homeostasis of T lymphocytes. LÄS MER

  5. 14. T-cell responses to Helicobacter pylori in humans and a possible role of regulatory T cells

    Författare :Anna Lundgren; Göteborgs universitet; []
    Nyckelord :Helicobacter pylori; mucosal immunology; stomach; duodenum; asymptomatic; duodenal ulcer; gastric adenocarcinoma; T cells; regulatory T cells; dendritic cells; T-cell recruitment;

    Sammanfattning : Helicobacter pylori colonize the stomach and areas of gastric metaplasia in the duodenum. The bacteria induce both local and systemic immune responses, but despite this, the infection normally persists for life and causes chronic gastritis in all infected subjects and peptic ulcers or gastric cancer in 10-20% of infected individuals. LÄS MER

  7. 15. Cartilage Tissue Engineering. A study on how to improve cartilage repair

    Författare :Sebastian Concaro; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cartilage tissue engineering Orthopaedics Knee Biomaterials;

    Sammanfattning : One of the first examples of musculoskeletal tissue engineering is autologous chondrocyte implantation (ACI).The first patient with a cartilage lesion was operated with ACI in 1987 and at that time suspension implantation was used. LÄS MER