Sökning: "brain region heterogeneity"

Visar resultat 6 - 10 av 13 avhandlingar innehållade orden brain region heterogeneity.

  1. 6. Towards new tools for clinical evaluation and visualization of tumor growth in patients with glioma

    Författare :Kenney Roy Roodakker; Anja Smits; Anne-Marie Landtblom; Elna-Marie Larsson; Jan J. Heimans; Uppsala universitet; []
    Nyckelord :PROX1; Histology; MRI; PET; Epilepsy; Co-registration; Neurology; Neurologi;

    Sammanfattning : Gliomas are derived from glial cells and are the most common type of primary brain tumors in adults. Gliomas are classified by the World Health Organization (WHO) according to their malignancy grade and histological and molecular features. Malignancy grades range from I to IV. WHO grade I tumors are benign tumors, mostly occurring in childhood. LÄS MER

  3. 7. Cell states along oligodendrocyte development and disease

    Författare :David van Bruggen; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The brain, one of the most complex organs in the body, where an immense diversity of cell states emerges from simple structure, where function arises from sets of regulatory principles and pattern persist where individual cells do not. Revealing the regulatory underpinnings of the brain, from unspecified cell states to diversity, is paramount for achieving a thorough understanding of the development process and generating insight into the disease states of the brain. LÄS MER

  4. 8. Diagnostic Evaluation of Schizophrenia for Genetic Studies

    Författare :Birgit Ekholm; Rolf Adolfsson; Erik Jönsson; Göran Sedvall; Leif Lindström; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Psychiatry; Schizophrenia; Diagnostic evaluation; Molecular genetic studies; Linkage; Association; Psykiatri; Psychiatry; Psykiatri; psykiatri; Psychiatry;

    Sammanfattning : Schizophrenia is one of the most severe mental disorders. Heredity is accepted as a major causative factor. To find molecular mechanisms behind schizophrenia, patient materials with reliable and valid diagnoses must be identified. LÄS MER

  5. 9. Integrative Modeling of Epigenetic Regulation in Human Disease

    Författare :Xi Lu; Xingqi Chen; Chandrasekhar Kanduri; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Glioblastoma; Cross-species; Glioblastoma stem cell; Dravet syndrome; ATAC-seq; Single-cell multi-omics technology;

    Sammanfattning : Glioblastoma is the most common and aggressive primary brain tumor. Standard of treatment prove ineffective, leading to tumor recurrence and an average survival rate of 14 months. This treatment resistance is attributed to both inter-tumor and intra-tumor heterogeneity observed across diverse tumor samples and within individual cells. LÄS MER

  7. 10. Fibrosis in the central nervous system : the role of perivascular cells

    Författare :Daniel Holl; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Regeneration in the adult mammalian central nervous system (CNS) is very limited. One limiting factor is the formation of chronic scar tissue, which inhibits axonal regeneration and functional recovery. LÄS MER