Sökning: "Wnt5a"

Visar resultat 21 - 25 av 28 avhandlingar innehållade ordet Wnt5a.

  1. 21. Bone and Cartilage Regeneration: Wnt Signaling Pathway in Healing

    Författare :Anna Thorfve; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Wnt signaling pathway; Osteoarthritis; Bone regeneration; Lithium;

    Sammanfattning : The Wnt signaling pathway plays a central role in bone and cartilage embryonic development, processes that are recapitulated during regeneration. Imbalance in such well conserved and complex system often contributes to numerous diseases, whereas controlled modulation of the Wnt signaling activity is an attractive target e.g. LÄS MER

  3. 22. Forkhead Genes in Mammalian Development

    Författare :Henrik Landgren; Göteborgs universitet; []
    Nyckelord :Development; Forkhead;

    Sammanfattning : This thesis concerns aspects of Forkhead gene biology and it’s relation to mammalian development. Genes from three subclasses are discussed, Foxj3, Foxf1 and f2, and Foxe3. LÄS MER

  4. 23. Transcriptional regulation of ribosomal RNA gene : actin, myosin and beyond

    Författare :Aishe Angeletti Sarshad; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : In the eukaryotic cell nucleus, actin and nuclear myosin 1c (NM1) are key regulators of RNA polymerase I (Pol I) transcription and function across the entire ribosomal RNA biogenesis pathway. At the gene level, actin interacts with Pol I and together with NM1 they have been suggested to facilitate assembly of Pol I at the gene promoter. LÄS MER

  5. 24. The Wnt pathway in ventral midbrain dopaminergic differentiation

    Författare :Diogo Ribeiro; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Parkinson’s disease (PD) is a debilitating neurodegenerative disease in which dopaminergic (DA) neurons in the substantia nigra are lost. Current treatments such as administration of levodopa (L-DOPA) are initially effective but the disease eventually progresses, highlighting the need for a treatment that restores and maintains the otherwise lost functions. LÄS MER

  7. 25. ROR1 : a novel receptor tyrosine kinase with unique therapeutic potentials in chronic lymphocytic leukemia

    Författare :Amir Hossein Daneshmanesh; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Chronic lymphocytic leukemia (CLL) is characterized by the accumulation of small B lymphocytes in blood, bone marrow, lymph nodes and other lymphoid tissues. CLL is the most common leukemia in the Western world. Despite significant advances in understanding the pathogenesis, CLL is still a disease with no available cure. LÄS MER