Sökning: "Wnt5a"

Visar resultat 11 - 15 av 28 avhandlingar innehållade ordet Wnt5a.

  1. 11. Mechanisms of Wnt signaling : from embryonic stem cells to dopaminergic neurons

    Författare :Lukas Cajanek; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The ability of a cell to respond in a specific way to certain signals represents key biological phenomena governing development of multicellular organism. Cellular signaling regulates all aspects of cell biology such as proliferation, migration, differentiation, and death. LÄS MER

  3. 12. Immunosuppressive Myeloid Cells in Breast Cancer and Sepsis

    Författare :Caroline Bergenfelz; Institutionen för translationell medicin; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : Immune cells play paradoxical roles in cancer progression. On one hand, the immune system protects us against tumor development by recognizing and eliminating cancerous cells. LÄS MER

  4. 13. Identification of novel Wnt/PCP signaling regulators and their role in midbrain dopaminergic neuron development and Parkinson's disease

    Författare :Alena Salašová; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Wnt signaling controls a wide spectrum of complex cell responses during prenatal development, in the adulthood and during disease. In this doctoral study, we have identified and explored novel regulatory components of Wnt/Planar Cell Polarity (PCP) pathway and their function in various cellular processes during embryogenesis and central nervous system (CNS) development. LÄS MER

  5. 14. Biomarkers in sepsis and other severe infections

    Författare :Helena Janols; Enheten för infektionssjukdomar; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; immunosuppression; myeloid-derived suppressor cells; T cells; dendritic cells; monocytes; sepsis; Biomarkers;

    Sammanfattning : Infectious diseases constitute a major global health problem. The presenting clinical picture results from a mixture of direct toxic actions by the microbiological agent and of the immune response mounted by the host. LÄS MER

  7. 15. Mechanisms controlling midbrain dopaminergic neuron development

    Författare :Shanzheng Yang; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The degeneration of midbrain dopaminergic (mDA) neurons accounts for some of the main motor symptoms of Parkinson’s disease (PD). Efforts during the last decades have focused on understanding how mDA neurons are generated and maintained with the hope of developing novel stem cell-based replacement therapies. LÄS MER