Sökning: "Wnt5a"

Visar resultat 16 - 20 av 28 avhandlingar innehållade ordet Wnt5a.

  1. 16. Wnt/beta-catenin signaling in midbrain dopaminergic neurons

    Författare :Nina Rawal; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Dopamine; neuron; development; beta-catenin; Writ; Parkin; Parkinson s disease;

    Sammanfattning : Parkinson's disease (PD) is caused by a progressive degeneration of the dopaminergic (DA) neurons of the substantia nigra. However, the mechanisms underlying the degeneration remain elusive and there is no cure for P1) at present. LÄS MER

  3. 17. Nuclear receptor and Wnt function in developing dopaminergic neurons

    Författare :Kyle Matthew Sousa; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The progressive degeneration of dopaminergic neurons in the substantia nigra is one of the major pathological events associated with Parkinson’s Disease. Dopaminergic (DA) cell replacement therapy has emerged in recent years as a possible approach towards treating Parkinsonism. LÄS MER

  4. 18. Survival and differentiation of central noradrenergic neurons

    Författare :Pontus Holm; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : About half of all central noradrenergic (NA) neurons reside in the locus coeruleus (LC). Projections from the LC reach target regions throughout the entire brain and regulate a variety of functions, such as mood, vigilance, arousal, sleep, attention and memory acquisition. LÄS MER

  5. 19. A Muscle Perspective on the Pathophysiology of Amyotrophic Lateral Sclerosis : Differences between extraocular and limb muscles

    Författare :Vahid M. Harandi; Jingxia Liu; Fatima Pedrosa Domellöf; Per Stål; Fawzi Kadi; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neuromuscular junctions; Extraocular muscles; Skeletal muscle; Neurotrophic factor; Wnt; Motor neuron disease; Amyotrophic lateral sclerosis; SOD1G93A mice; molekylärbiologi; Molecular Biology;

    Sammanfattning : Background: Amyotrophic lateral sclerosis (ALS) is a late-onset progressive neurodegenerative disorder. ALS has been traditionally believed to be primarily a motor neuron disease. LÄS MER

  7. 20. Aniridia-related keratopathy : structural changes, signaling pathways and clinical aspects

    Författare :André Vicente; Fatima Pedrosa Domellöf; Berit Byström; Luis Abegão Pinto; Jing-Xia Liu; Anders Ivarsen; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; aniridia; aniridia-related keratopathy; PAX6; keratoplasty; fetal cornea; Notch1; Wnt; sonic hedgehog; mTOR; keratocyte; oftalmiatrik; ophthalmology;

    Sammanfattning : Aniridia is a congenital autosomal dominant, bilateral, panocular condition, caused by haploinsufficiency of the Pax6 transcription factor. Aniridia-related keratopathy (ARK) significantly affects vision and quality of life in these patients. LÄS MER