Sökning: "THP-1"

Visar resultat 21 - 25 av 30 avhandlingar innehållade ordet THP-1.

  1. 21. Effects of hypoxia on macrophage function in atherosclerosis

    Författare :Ellen Knutsen Rydberg; Göteborgs universitet; []
    Nyckelord :atherosclerosis; hypoxia; macrophage; IL-8; oxidized LDL; oxysterols; 15-lipoxygenase-2;

    Sammanfattning : Atherosclerosis is a complex disease, which affects large and medium sized arteries and is characterized by an arterial wall thickening. A constant supply of oxygen is needed to maintain cell functions in the atherosclerotic plaque. The oxygen distribution to the cells in the arterial wall depends on diffusion. LÄS MER

  3. 22. Neuroinflammation and its resolution in Alzheimer's disease

    Författare :Ying Wang; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Alzheimer's disease (AD) is the most common dementia with high prevalence among an increasing aged population. Despite the existence of symptom-reliving drugs for AD, the clinical trials performed until now have failed to find drugs that cure or stop the progression of AD. New perspectives and strategies for treatments are therefore direly needed. LÄS MER

  4. 23. Skeletal muscle matrix metalloproteinase and exercise in humans

    Författare :Eric Rullman; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Skeletal muscle is a highly plastic tissue; it has a great capacity to adapt to environmental demands throughout life. The structural and functional changes that occur in response to exercise training are well characterized whereas much less is known about these adaptive processes at the cellular and molecular levels. LÄS MER

  5. 24. CTLA-4 expression, regulation and associations in autoimmune myasthenia gravis

    Författare :XiongBiao Wang; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Cytotoxic-T-lymphocyte-associated antigen 4 CTLA-4 ; Myasthenia gravis MG ; Immune inhibitory receptor; Autoimmune disease; Genetic polymorphism.;

    Sammanfattning : Myasthenia gravis (MG) is a neuromuscular disease with muscle weakness due to an autoimmune attack against the nicotinic acetylcholine receptor (nAChR) on the skeletal muscle endplate. Cytotoxic-T-lymphocyte-associated antigen 4 (CTLA-4) plays a global inhibitory role in the immune system and has a crucial role in autoimmunity. LÄS MER

  7. 25. Human C-reactive protein : genetic and hormonal regulation and role in atherogenesis

    Författare :Alexander Kovacs; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Although in decline in the developed world CHD is still the number one killer. The decline is thought to be due to better risk prevention and treatment. C-reactive protein (CRP) has emerged as an marker of CHD. It is associated with several of the major risk factors of CHD. LÄS MER