Sökning: "Signaling pathways"

Visar resultat 41 - 45 av 713 avhandlingar innehållade orden Signaling pathways.

  1. 41. Bone and Cartilage Regeneration: Wnt Signaling Pathway in Healing

    Författare :Anna Thorfve; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Wnt signaling pathway; Osteoarthritis; Bone regeneration; Lithium;

    Sammanfattning : The Wnt signaling pathway plays a central role in bone and cartilage embryonic development, processes that are recapitulated during regeneration. Imbalance in such well conserved and complex system often contributes to numerous diseases, whereas controlled modulation of the Wnt signaling activity is an attractive target e.g. LÄS MER

  3. 42. Combination Therapies Targeting PDGF and VEGF Signaling Pathways in Solid Tumors

    Författare :Agnieszka Kłosowska-Wardęga; Carina Hellberg; Carl-Henrik Heldin; Per Lindahl; Uppsala universitet; []
    Nyckelord :MEDICINE; MEDICIN; Oncology; Onkologi;

    Sammanfattning : Vascular endothelial growth factor (VEGF) and platelet-derived growth factor (PDGF) are independently involved in several cancer-associated mechanisms including autocrine stimulation of cancer cells, stimulation of tumor angiogenesis and regulation of interstitial fluid pressure (IFP). The scope of this thesis was to investigate the combinatory effect of anti-VEGF and anti-PDGF treatment on tumor angiogenesis and tumor IFP. LÄS MER

  4. 43. Cellular pathways and molecular regulation of hematopoietic stem cells

    Författare :Kristina Anderson; Stamcellscentrum (SCC); []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; β-catenin.; lineage commitment; hematopoietic stem cells; lineage priming; Wnt signaling pathway; biphenotypic cells; PAX5;

    Sammanfattning : Hematopoietic stem cells (HSCs) are defined by their unique properties to self-renew and differentiate into all hematopoietic cell lineages. Residing in the bone marrow (BM), adult HSCs are organized in a hierarchy of cells that differ in their self-renewal and proliferative capacity. LÄS MER

  5. 44. Biological consequences of endothelial cell signaling

    Författare :Ross Smith; Lena Claesson-Welsh; Przemyslaw Sapieha; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; VEGFR2; Mechanosensing; Retinopathy; Biologi; Biology;

    Sammanfattning : Endothelial cells make up the inner lining of blood and lymphatic vessels, where they participate in functions vital to survival of the tissue; endothelial cells maintain vessel integrity, dynamically respond to the changing metabolic needs of tissues, and participate in many tissue-specific functions. Endothelial cells sense environmental cues which initiate signal transduction pathways that regulate behavior. LÄS MER

  7. 45. Analysis of signaling pathway activity in single cells using the in situ Proximity Ligation Assay

    Författare :Linda Arngården; Ola Söderberg; Niclas Karlsson; Uppsala universitet; []
    Nyckelord :cell signaling; Wnt; Hippo; TGFB; Molekylär medicin; Molecular Medicine;

    Sammanfattning : A cell that senses signals from its environment uses proteins for signal transduction via post translational modifications (PTMs) and protein- protein interactions (PPIs) from cell membrane into the nucleus where genes controlling cell proliferation, differentiation and apoptosis can be turned on or off, i.e. LÄS MER