Sökning: "PAX5"

Visar resultat 1 - 5 av 12 avhandlingar innehållade ordet PAX5.

  1. 1. Cellular pathways and molecular regulation of hematopoietic stem cells

    Författare :Kristina Anderson; Stamcellscentrum (SCC); []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; β-catenin.; lineage commitment; hematopoietic stem cells; lineage priming; Wnt signaling pathway; biphenotypic cells; PAX5;

    Sammanfattning : Hematopoietic stem cells (HSCs) are defined by their unique properties to self-renew and differentiate into all hematopoietic cell lineages. Residing in the bone marrow (BM), adult HSCs are organized in a hierarchy of cells that differ in their self-renewal and proliferative capacity. LÄS MER

  3. 2. Molecular mechanisms in lymphoid restriction : securing the B lineage fate

    Författare :Josefine Åhsberg; Mikael Sigvardsson; Jan-Ingvar Jönsson; Charles G. Mullighan; Linköpings universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : With the work in this thesis I have aimed to deepen the understanding of the mechanisms behind the development of different blood cell lineages with a specific focus on B cell development.To understand the interplay between extracellular signaling and transcription factor networks in early lymphoid development we investigated the functional collaborations of FLT3 and IL7R. LÄS MER

  4. 3. Deciphering mechanisms of transcriptional activation and repression in B lymphocytes

    Författare :Stephen Malin; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : During the course of evolution, our immune system has developed, to defend us against infections, a diverse number of specialized cell types. Immunoglobulin producing B lymphocytes are produced by the differentiation of hematopoietic stem cells (HSC) into gradually more lineage-restricted progenitors. LÄS MER

  5. 4. Transcriptional mechanisms directing terminal differentiation of B lineage cells

    Författare :Ylva Linderson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The interaction between the B cell receptor (surface immunoglobulin) and its ligand (antigen) can result in extensive cell growth and induction of differentiation. The terminally differentiated B cell fulfills the ultimate purpose of B cell existence: to secret antibodies in order to protect the organism against invading pathogens. LÄS MER

  7. 5. ELUCIDATING REGULATORY NETWORKS PROMOTING B-CELL DEVELOPMENT

    Författare :Eva Welinder; Institutionen för experimentell medicinsk vetenskap; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : B-cells are an essential part of our adaptive immune system. A network of transcription factors together with external signals facilitate the gradual developmental progression from progenitor cells towards the B-cell fate. Several key factors participating in this network have been identified. LÄS MER