Sökning: "TGFB"
Visar resultat 1 - 5 av 19 avhandlingar innehållade ordet TGFB.
1. Analysis of signaling pathway activity in single cells using the in situ Proximity Ligation Assay
Sammanfattning : A cell that senses signals from its environment uses proteins for signal transduction via post translational modifications (PTMs) and protein- protein interactions (PPIs) from cell membrane into the nucleus where genes controlling cell proliferation, differentiation and apoptosis can be turned on or off, i.e. LÄS MER
2. FoxF genes in development and disease
Sammanfattning : Forkhead transcription factors of the FoxF group are important during embryonic de-velopment, and mutation of either of the members, Foxf1 and Foxf2, has fatal conse-quences. In this thesis, I present our recent findings about the mechanism of action of FoxF genes in development and disease. LÄS MER
3. Non-canonical TGFb signaling pathways in prostate cancer
Sammanfattning : Prostate cancer is the second leading cause of cancer-related death in men in the Western world. Deregulation of transforming growth factor β (TGFβ) signaling pathway is frequently detected in prostate cancer and contributes to tumor growth, migration, and invasion. LÄS MER
4. Molecular studies of pancreatic cancer: Characterization of the transforming growth factor beta signaling pathway
Sammanfattning : In the present thesis, genetic abnormalities in pancreatic cancer were studied, with special emphasis on alterations of components involved in the transforming growth factor beta (TGFB) signaling pathway. In the first study, fluorescence in situ hybridization and cytogenetic analyses revealed aberrations of chromosome 18 in all 13 pancreatic carcinoma cell lines studied, in particular frequent breaks close to the centromere of chromosome arm 18q. LÄS MER
5. Functional and bioinformatical studies of the TGFb superfamily : identification and characterization of ALK7
Sammanfattning : The transforming growth factor beta (TGFbeta) superfamily of polypeptide growth factors encompasses more than 30 diverse mammalian members. They are involved in most cellular processes, ranging from cell proliferation and differentiation, to survival and death. Loss of TGFbeta activity is coupled to tumor development and many other disorders. LÄS MER