Sökning: "Raf"

Visar resultat 21 - 25 av 38 avhandlingar innehållade ordet Raf.

  1. 21. Molecular Signatures of Cancer

    Författare :Esther Edlundh-Rose; Joakim Lundeberg; Peter Södervist; KTH; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; : BRAF; NRAS; MGMT; methylation; pyrosequencing; microarray technology; gene expression analysis; Molecular biology; Molekylärbiologi;

    Sammanfattning : Cancer is an important public health concern in the western world, responsible for around 25% of all deaths. Although improvements have been made in the diagnosis of cancer, treatment of disseminated disease is inefficient, highlighting the need for new and improved methods of diagnosis and therapy. LÄS MER

  3. 22. Molecular genetic aspects of colorectal cancer development

    Författare :Karin Fransén; Annika Lindblom; Linköpings universitet; []
    Nyckelord :MEDICINE; MEDICIN;

    Sammanfattning : Colorectal cancer (CRC) is one of the most common cancer diseases in the world after lung and female breast cancer and approximately 945 000 new cases are diagnosed every year. CRC is caused by genetic alterations in the DNA, which results in cell cycle acceleration, escape from apoptosis, senescence, angiogenesis, invasion and metastasis. LÄS MER

  4. 23. Role of the map kinase pathways in maintenance of the transformed phenotype

    Författare :Sofia Ljungdahl; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :ras; c-jun; MAPK; carcinogenesis; transformation;

    Sammanfattning : In order to interfere pharmacologically with tumor growth and metastasis, it is of great importance to understand the status of the signal transduction systems in tumor cells. The effect of various oncogenes on cellular signal transduction events has largely been studied in short term experiments. LÄS MER

  5. 24. STAT5 expression and regulation in mammary epithelial cells

    Författare :Hanne Olsen; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :STAT5; JAK2; PPAR-gamma; ER; MAPK; mammary epithelial cell differentiation;

    Sammanfattning : The mammary gland of an adult mammal undergoes cycles of proliferation and differentiation influenced by growth factors, peptide, and steroid hormones, e.g. epidermal growth factor (EGF), prolactin (PRL) and estrogen (E). LÄS MER

  7. 25. Mechanisms of insulin signaling and the role of caveolae

    Författare :Santiago Parpal; Pam Fredman; Linköpings universitet; []
    Nyckelord :MEDICINE; MEDICIN;

    Sammanfattning : Insulin regulates metabolic as well as mitogenic processes in target cells, involving a large number of mediators of signal transduction. In its role as a growth factor, insulin stimulates cell growth, in a process we demonstrate requires the participation of the Raf-1 kinase. LÄS MER