Sökning: "RET kinase"
Visar resultat 16 - 20 av 22 avhandlingar innehållade orden RET kinase.
16. Neurotrophic Factor Receptors in the Normal and Injured Visual System : Focus on Retinal Ganglion Cells
Sammanfattning : The focus of this thesis is the life and death of adult retinal ganglion cells (RGCs). RGCs are neurons that convey visual information from the retina to higher centers in the brain. LÄS MER
17. Telomerase activation and its clinical implications in human thyroid tumors
Sammanfattning : Telomerase is a ribonucleoprotein enzyme. The catalytic and rate-limiting component of telomerase is referred to as telomerase reverse transcriptase (TERT) that plays an important role in telomere maintenance, cell immortalization and malignant transformation. LÄS MER
18. Expression and function of GDNF family ligands and receptors in the nervous system
Sammanfattning : The search for novel neurotrophic factors promoting dopamine uptake and the survival of central dopaminergic neurons led to the discovery of a novel neurotrophic factor termed glial cell-line derived neurotrophic factor (GDNF). GDNF, neurturin (NTN), artemin (ART) and persephin (PSP) belong to the GDNF family ligands, and are potent survival-promoting factors for subsets of central and peripheral neurons. LÄS MER
19. Computer-aided drug design approaches in developing anti-cancer inhibitors
Sammanfattning : The thesis entitled “computer-aided drug design approaches in developing anti-cancer drug” is divided into a total of six chapters. In the first chapter, an overview of drug discovery and development are introduced. LÄS MER
20. Some aspects of nuclear receptor function in the CNS : novel roles of Nurr1 and RXR in developing and mature neurons
Sammanfattning : The nuclear receptor superfamily comprises the receptors for steroid hormones, thyroid hormone, vitamin D and retinoids. The family also includes a number of receptors that lack identified ligands, and are therefore referred to as orphan receptors. LÄS MER
