Sökning: "Pierre-Jean Corringer"

Hittade 1 avhandling innehållade orden Pierre-Jean Corringer.

1. 1. Allosteric modulation of pentameric ligand-gated ion channels by general anesthetics

   Författare :Stephanie A. Heusser; Erik Lindahl; Pierre-Jean Corringer; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Biochemistry; biokemi;

   Sammanfattning : Pentameric ligand-gated ion channels (pLGICs) are key components of fast synaptic transmission and are targets of neuroactive drugs such as benzodiazepines, alcohol and muscle relaxants. Although early theories of general anesthesia suggested non-specific lipid interaction as the mechanism of anesthetic action, it has now become evident that they too bind to pLGICs. LÄS MER