Sökning: "Pharmacophore"

Visar resultat 16 - 16 av 16 avhandlingar innehållade ordet Pharmacophore.

1. 16. Electrophysiology-based investigations of G protein-coupled receptor pharmacology

   Författare :Richard Ågren; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : G protein-coupled receptors (GPCRs) constitute targets for ~34% of approved drugs. The muscarinic acetylcholine M2 receptor (M2R) activates G protein-coupled receptor inward rectifying potassium (GIRK) channels in the central nervous system and heart. Membrane potential modulates agonist potency at several GPCRs. LÄS MER