Sökning: "PXR"

Visar resultat 11 - 12 av 12 avhandlingar innehållade ordet PXR.

  1. 11. Regulation of Vitamin D 25-hydroxylases : Effects of Vitamin D Metabolites and Pharmaceutical Compounds on the Bioactivation of Vitamin D

    Författare :Maria Ellfolk; Kjell Wikvall; Maria Norlin; Olavi Pelkonen; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; CYP2D25; vitamin D 25-hydroxylase; transcriptional regulation; vitamin D; CYP2R1; CYP2J2; CYP27A1; phenobarbital; efavirenz; fibroblast; LNCaP; Pharmaceutical biochemistry; Farmaceutisk biokemi;

    Sammanfattning : A 700bp portion of the promoter of CYP2D25, the porcine microsomal vitamin D 25-hydroxylase was isolated and sequenced. The computer analysis of the sequence revealed the existence of a putative VDRE at 220 bp upstream of the transcription start site. LÄS MER

  3. 12. On the role of cytochrome P450 3A4 in the metabolism of cholesterol and bile acids

    Författare :Karl Bodin; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Oxysterols; 4beta-hydroxycholesterol; 1beta-hydroxylated bile acids; 22hydroxylated bile acids; 3-oxo bile acids; gas chromatography-mass spectrometry;

    Sammanfattning : The origin of 4beta-hydroxycholesterol, a major oxysterol in human circulation, has previously been unknown. In this thesis, the formation and elimination of this compound are investigated by various techniques. The biological effects of 4beta-hydroxycholesterol are also discussed. LÄS MER