Sökning: "4beta-hydroxycholesterol"

Hittade 2 avhandlingar innehållade ordet 4beta-hydroxycholesterol.

  1. 1. Studies on the oxysterols 4alpha- and 4beta-hydroxycholesterol

    Författare :Hanna Nylén; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Cytochrome P450 (CYP) enzymes catalyze the metabolism of both foreign and endogenous substances such as drugs and steroids. Enzymes in subfamily CYP3A sum up to 30% of the total CYP content in the liver and metabolize about 50% of all drugs. LÄS MER

  3. 2. On the role of cytochrome P450 3A4 in the metabolism of cholesterol and bile acids

    Författare :Karl Bodin; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Oxysterols; 4beta-hydroxycholesterol; 1beta-hydroxylated bile acids; 22hydroxylated bile acids; 3-oxo bile acids; gas chromatography-mass spectrometry;

    Sammanfattning : The origin of 4beta-hydroxycholesterol, a major oxysterol in human circulation, has previously been unknown. In this thesis, the formation and elimination of this compound are investigated by various techniques. The biological effects of 4beta-hydroxycholesterol are also discussed. LÄS MER