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1. 1. Transcription factors regulating the Btk promoter

   Författare :Susanne Müller; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Btk; X-linked agammaglobulinemia; transcription factors; repression; synergism; Sp 1; Sp3; PU.l; Spi-B; genetherapy.;

   Sammanfattning : Bruton's agammaglobulinemia tyrosine kinase (Btk) is a cytoplasmic tyrosine kinase-related to the Src family of kinases. Mutations in various parts of the gene have been shown to lead to X-linked agammaglobulinemia, an immunodeficiency disease which is characterized by a defect in B-cell development. LÄS MER