Sökning: "PDGF-A"
Visar resultat 11 - 15 av 17 avhandlingar innehållade ordet PDGF-A.
11. Studies of VEGF-B and novel PDGFs in tumorigenesis and angiogenesis
Sammanfattning : The family of VEGF/PDGF growth factors and their receptors are important regulators of tumorigenesis and angiogenesis. VEGFs have been shown to play important roles in development of both blood and lymphatic vessels by effect on endothelia cells. LÄS MER
12. Platelet-derived growth factor-induced signal transduction
Sammanfattning : Platelet-derived growth factor (PDGF), a potent mitogen for mesenchymal cells, elicits its effects by binding to cell surface tyrosine kinase receptors, denoted α- and β-receptors. This thesis describes the mechanism of interaction between stimulated PDGF receptors and various intracellular molecules. LÄS MER
13. Modulation of PDGF Receptor Signaling via the Phosphatase SHP-2 and the Docking Protein Gab1
Sammanfattning : x.... LÄS MER
14. Regulation of the platelet-derived growth factor β-receptor
Sammanfattning : Growth factors are important signalling molecules, regulating cell growth, as well as cell movement, differentiation and apoptosis. They bind to specific receptors on the cell surface causing activation of the receptors. Activated receptors then attract adaptor molecules that brings the signal further into the cell. LÄS MER
15. Proteolytic activation and biological functions of the novel PDGFs
Sammanfattning : The platelet-derived growth factors (PDGFs) and their cell surface receptors regulate growth and migration of connective tissue cells of both the vascular network and other organ systems. They are known to be important for normal development and processes, such as wound healing and angiogenesis, but have also been implicated in many pathological conditions, such as malignancies and fibrotic disease. LÄS MER
