Sökning: "PDGF-A"
Visar resultat 6 - 10 av 17 avhandlingar innehållade ordet PDGF-A.
6. Growth control mechanisms in normal and neoplastic mammalian cells
Sammanfattning : The main theme of the studies presented in this thesis is, the growth control mechanisms whose loss in normal cells predispose to or cause cancer. The balance between growth inhibitory and stimulatory mechanisms is crucial for the development and maintenance of a normal animal. LÄS MER
7. A PDGFRalpha perspective on PDGF signalling in developmental and pathological processes
Sammanfattning : Platelet-derived growth factors PDGFs are a family of ligands and receptors that regulate multiple processes of paramount importance during embryonic development. They are also involved in several pathological events, spanning from tumours to fibrotic diseases. LÄS MER
8. Studies of the novel PDGFs, focusing on PDGF-D
Sammanfattning : Thirty years ago the classical platelet-derived growth factors (PDG17s), PDGF-A and PDGF-B were discovered. For a long time they were thought to be the only PDG17 isoforms to exist, but recently two novel PDGF molecules were identified, namely PDGF-C and PDGF-D. LÄS MER
9. Angiogenic growth factors : mechanism of action and function in vascular development
Sammanfattning : The mature vascular system is composed of a network of blood vessels organized into arteries, capillaries, and veins. The vessels are composed of endothelial cells surrounded by smooth muscle cells and embedded in a specialized basement membrane. LÄS MER
10. Modeling PDGF-driven gliomagenesis in the mouse
Sammanfattning : Gliomas are the most common form of brain tumors, with glioblastoma being the most aggressive form. Glioblastoma is characterized by a number of genetic aberrations, among them amplification and overexpression of platelet-derived growth factor receptor alpha (PDGFRA) that sometimes occurs together with inactivating mutations or loss of the tumor suppressor p53 (TP53). LÄS MER