Sökning: "Proline derivatives"

Visar resultat 1 - 5 av 7 avhandlingar innehållade orden Proline derivatives.

  1. 1. Amino acid-catalyzed synthesis of amino acid derivatives : Application and semi-synthesis of Paclitaxel, Docetaxel and their derivatives

    Författare :Pawel Dziedzic; Armando Córdova; Stephen Hanessian; Stockholms universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Organocatlysis; amino acids; syntesis; Taxol and Taxotere derivatives; Chemistry; Kemi; organisk kemi; Organic Chemistry;

    Sammanfattning : This thesis deals with different applications of organocatalysis, where amino acid derivatives and small peptides are applied as catalysts. First, the development of environmentally friendly aldol reactions, carried out in aqueous media is illustrated. The corresponding β-hydroxy ketones are formed with ee´s up to 99%. LÄS MER

  2. 2. Development of organocatalytic asymmetric transformations

    Författare :Ismail Ibrahem; Armando Cordova; Stephen Hanessian; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Asymmetric Catalysis; α-amino acids; Aldehydes; Ketones; α-Aminomethylation; Aziridination; Hydrophosphination; Diarylprolinol; Proline derivatives; Organic synthesis; Organisk syntes; Organic Chemistry; organisk kemi;

    Sammanfattning : The ability of amino acids and amino acid derivatives to mediate various organocatalytic asymmetric transformations has been investigated and applied in the development of various reactions. This work describes the development of a direct catalytic asymmetric α-aminomethylation of ketones and aldehydes, a catalytic asymmetric aziridination, hydrophosphination and amination of α,β-unsaturated aldehydes. LÄS MER

  3. 3. Development of highly enantioselective organocatalyzed transformations

    Författare :Palle Breistein; Armando Córdova; Mittuniversitetet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Asymetric catalysis; aldehydes; proline derivatives; transition metals; Friedel-Crafts; conjugate addition; boration; α-alkylation;

    Sammanfattning : .... LÄS MER

  4. 4. Development of New Methodology in Organic Synthesis: Lewis Acid-Mediated Rearrangements of Ammonium Ylides and Addition of 1, 3-bis(silyl) propenes to Aldehydes

    Författare :Pavel Tuzina; Peter Somfai; Ari Koskinen; KTH; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; asymmetric; amino acid; ammonium ylide; Lewis acid; microwave irradiation; Organic synthesis; Organisk syntes;

    Sammanfattning : This thesis deals with the development of new methodologies in organicsynthesis. The main focus is on the development of Lewis acid-mediated [1,2]-rearrangements of ammonium ylides and the novel addition of 1,3-bis(silyl)propenes to carbonyl compounds. LÄS MER

  5. 5. Enantioseparation of drugs and related compounds using chiral mobile phase additives

    Författare :Ngoc Hang Huynh; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutical chemistry; Farmaceutisk kemi; Pharmaceutical chemistry; Farmaceutisk kemi; analytisk farmaceutisk kemi; Analytical Pharmaceutical Chemistry;

    Sammanfattning : Neutral and anionic chiral mobile phase additives have been employed to separate enantiomers of drugs and related compounds using aqueous buffer solution and hydro-organic solvent mixtures as mobile phases.Ester derivatives of tartaric acid, e. g. LÄS MER