Sökning: "NK education"

Visar resultat 11 - 15 av 19 avhandlingar innehållade orden NK education.

  1. 11. Improving NK cell-based immunotherapy of cancer by exploration of migration and inhibitory receptor-ligand interactions

    Författare :Filip Segerberg; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The possibility to utilize the immune system as a mean to target malignantly transformed cells has emerged as a novel treatment modality during the last decades and is a field that is under rapid development. Natural Killer (NK) cells are immune cells with an intrinsic ability to recognize and lyse tumor-transformed cells. LÄS MER

  3. 12. Natural killer cell education under conditions of perturbed sensing of MHC : studies in MHC-I mosaic and chimaeric mice

    Författare :Sadia Salam; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Natural killer (NK) cells are innate lymphocytes that play a role in infections, tumours and transplantation. Their activating and inhibitory receptors sense cell surface ligands on potential target cells. LÄS MER

  4. 13. Natural killer cell tolerance : influence of the MHC class I expression in the host

    Författare :Maria H Johansson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :NK cells; MHC class 1; tolerance; transgenic mice; Ly49;

    Sammanfattning : Development of self-tolerance in the immune system is characterized by somatic processes aiming at permanently eliminating, or silencing, potentially autoreactive lymphocytes. Such tolerance mechanisms are of outmost importance if autoimmunity is to be avoided. LÄS MER

  5. 14. The ontogeny and regulation of human natural killer cells

    Författare :Martin A Ivarsson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Natural Killer (NK) cells are members of the innate lymphoid cell (ILC) family and take part in the detection and eradication of virus-infected and transformed cells. In this thesis, together with my colleagues I have investigated how NK cells and other ILCs develop and function during human fetal development, how NK cells are functionally regulated (educated) via the activating receptor KIR2DS1, and how NK cells in our body are affected during the early phase of an acute viral infection. LÄS MER

  7. 15. Single cell studies of natural killer cell immune surveillance

    Författare :Elin Forslund; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Our immune system protects us from microbes such as viruses, bacteria and parasitic worms. The immune system also plays a key role in fighting cancer and in carrying out a function termed ‘immune surveillance’, natural killer (NK) cells patrol tissues and participate in the elimination of transformed cells and established tumors. LÄS MER