Sökning: "NAFLD"

Visar resultat 21 - 25 av 34 avhandlingar innehållade ordet NAFLD.

  1. 21. Transcriptional control of liver metabolism and disease by nuclear receptor-corepressor networks

    Författare :Ning Liang; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Liver lipid metabolism is coordinated via transcriptional networks composed of transcription factors and coregulators. Disturbance of such networks leads to metabolic dysregulation and is linked to the progression of obesity-related metabolic disorders, such as non-alcoholic fatty liver disease (NAFLD) and cardiovascular disease. LÄS MER

  3. 22. Some epidemiological aspects of liver cirrhosis and hepatocellular carcinoma in Sweden

    Författare :Juan Vaz; Allmänmedicin och samhällsmedicin; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Liver cirrhosis; Hepatocellular carcinoma; Epidemiology; Socioeconomic Status; Survival Analysis; Etiology; Sweden;

    Sammanfattning : Background: Contemporary epidemiological studies examining incidence rates (IR) of cirrhosis and hepatocellular carcinoma (HCC) in Swedish populations are scarce. Cirrhosis and HCC are associated with a significant burden of health inequity and stigma. LÄS MER

  4. 23. Enhancing prediction and causal inference in metabolic dyshomeostasis

    Författare :Naeimeh Atabaki Pasdar; Genetisk och molekylär epidemiologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : This thesis is focused on two globally prevalent diseases: i) non-alcoholic fatty liver disease (NAFLD) and ii) type 2 diabetes (T2D), with an overall aim of improving prediction and causal inference in the context of these conditions. Our projects were mainly conducted using IMI DIRECT and UK Biobank datasets including multi-omics data, extensive environmental exposures, and biological intermediates. LÄS MER

  5. 24. The role of liver myeloid cells in obesity and metabolic disease

    Författare :Emelie Barreby; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Macrophages are tissue resident cells with diverse phenotypes and functions depending on their origin, localization and physiological context. In the liver, their main functions are to detoxify the blood from pathogens, debris and metabolic waste arriving to the liver through the systemic and portal circulation. LÄS MER

  7. 25. Elucidating causal relationships between energy homeostasis and cardiometabolic outcomes

    Författare :Pascal Mutie; Genetisk och molekylär epidemiologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Adiposity; causal inference; Cardiometabolic disease; Mendelian randomization;

    Sammanfattning : Energy metabolism dyshomeostasis is associated with multiple health problems. For example, abundant epidemiological data show that obesity and overweight increase the risk of cardiometabolic diseases and early mortality. LÄS MER