Sökning: "LRRK2"

Visar resultat 6 - 8 av 8 avhandlingar innehållade ordet LRRK2.

  1. 6. On genes involved in common neurological disorders : focus on Parkinson's disease

    Författare :Caroline Ran; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Parkinson’s disease and migraine are complex neurological disorders and it is likely that a combination of genetic risk factors are involved in the etiology of both these diseases. Papers in this thesis investigate candidate genes in the search of genetic risk factors contributing to disease. LÄS MER

  3. 7. Immunogenetics of Parkinson's disease: Translational studies from rodents to humans

    Författare :Itzia Jimenez; Translationell Neurogenetik; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; genetics; inflammation; α-synuclein; dopaminergic neurons; MHCII; Mhc2ta; Vra4; PFFs; microglia;

    Sammanfattning : Parkinson's disease (PD) is a complex neurodegenerative disease, characterized by a progressive lossof dopaminergic neurons (DN) in the substantia nigra (SN) that innervate the striatum (ST) and pathologicalaccumulation of alpha-synuclein (αsyn) protein in aggregates called Lewy bodies (LB) and Lewy neurites(LN). As a complex disease, PD presents a genetically heterogeneous origin. LÄS MER

  4. 8. Elucidation of the cell signaling pathways mediating innate immunity and host-pathogen interactions

    Författare :Neel R Nabar; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The ability to generate a robust immune response is integral to organismal homeostasis. Cells of the innate immune system are considered the first responders of immunity, and are therefore responsible for sensing both pathogens and endogenous danger signals and initiating a protective inflammatory response. LÄS MER