Sökning: "Jing Cen"

Hittade 1 avhandling innehållade orden Jing Cen.

1. 1. Free fatty acids and insulin hypersecretion studied in human islets

   Författare :Jing Cen; Peter Bergsten; Miriam Cnop; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; free fatty acids; palmitate; human islets; EndoC-βH1 cells; metformin; sorcin; insulin secretion; mitochondrial respiration; ER stress; human transcriptome array; Medical Cell Biology; Medicinsk cellbiologi;

   Sammanfattning : Free fatty acid (FFA) levels are increased in many obese subjects. High FFA levels stimulate the pancreatic beta-cells but have negative long-term effects. In obese children with high FFA levels circulating insulin concentration is high early in life but decline with age precipitating the development of type 2 diabetes mellitus (T2DM). LÄS MER