Sökning: "human transcriptome array"
Visar resultat 1 - 5 av 6 avhandlingar innehållade orden human transcriptome array.
1. Free fatty acids and insulin hypersecretion studied in human islets
Sammanfattning : Free fatty acid (FFA) levels are increased in many obese subjects. High FFA levels stimulate the pancreatic beta-cells but have negative long-term effects. In obese children with high FFA levels circulating insulin concentration is high early in life but decline with age precipitating the development of type 2 diabetes mellitus (T2DM). LÄS MER
2. Transcriptome-wide analysis in cells and tissues
Sammanfattning : High-throughput sequencing has greatly influenced the amount of data produced and biological questions asked and answered. Sequencing approaches have also enabled rapid development of related technological fields such as single-cell and spatially resolved expression profiling. LÄS MER
3. Transcriptome and Proteome Analysis using Signature Tags
Sammanfattning : With the full sequence of the human genome now available, anexciting era in biomedical research has started. The sequenceprovides information about all our genes and greatly increasesthe scope to compare genetic activities in different cells, toanalyze genetic variation between individuals and betweendifferent species and, most importantly, to investigatesystematically the whole genome in a gene-by-gene manner, andthus increase our understanding of gene function. LÄS MER
4. Statistical methods for the detection, analyses and integration of biomarkers in the human genome and transcriptome
Sammanfattning : Most human diseases have been shown to have a genetic basis that is linked to regulation of gene expression at the transcriptional or post-transcriptional level. In the central dogma of biology, deoxyribonucleic acid (DNA) is transcribed to messenger ribonucleic acid (mRNA), and then translated into proteins; dysfunction in any of these processes may contribute to the development of disease. LÄS MER
5. PARN - A Tale of A de-Tailor : Functional importance of poly(A) degradation in developmental and telomere biology disorders
Sammanfattning : Poly(A)-specific ribonuclease (PARN) is a eukaryotic 3’-5’exoribonuclease that removes poly(A) tails of many coding and non-coding RNAs. In this thesis, we have studied the physiological role of PARN. LÄS MER