Sökning: "IRS-1"

Visar resultat 6 - 10 av 28 avhandlingar innehållade ordet IRS-1.

  1. 6. Molecular mechanisms of insulin action in human skeletal muscle and adipose tissue : implications for diabetes and obesity

    Författare :Marie Björnholm; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Glucose transport; insulin signal transduction; skeletal muscle; adipose tissue; type 2 diabetes mellitus; obesity; very low calorie diet.;

    Sammanfattning : Studies of animal models of type 2 diabetes mellitus implicate that impaired insulin signal transduction to glucose transport accounts for whole body insulin resistance in skeletal muscle and adipose tissue. The overall aim of the present thesis was to determine insulin signal transduction to glucose transport in human skeletal muscle and adipose tissue from type 2 diabetic patients and obese insulin resistant subjects. LÄS MER

  3. 7. Effect of hyperglycemia on glucose transport and intracellular signal transduction in skeletal muscle

    Författare :Yuichi Kawano; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :skeletal muscle; glucose transport; insulin signaling; hyperglycemia; PKC; Akt kinase; GotoKakizaki rat; phlorizin; muscle fiber type;

    Sammanfattning : Recent studies revealing the components of insulin signal transduction have raised the question of whether the defects in insulin signaling account for disturbed glucose metabolism in people with NIDDM. The major focus of this thesis is to elucidate the role of insulin signal transduction in the development of peripheral insulin resistance. LÄS MER

  4. 8. Insulin signal transduction in skeletal muscle : special consideration for insulin resistance and diabetes

    Författare :Xiao Mei Song; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :exercise; fiber-type; glucose transport; hyperglycemia; obesity; signal transduction; skeletal muscle; NIDDM;

    Sammanfattning : This dissertation work is focused on the insulin-signal-transduction pathways to glucose transport in skeletal muscle from animal models of NIDDM. The overall objective is to determine the effectiveness of different pharmacological treatments to improve insulin action in skeletal muscle. LÄS MER

  5. 9. Studies of the adipose tissue in insulin resistance with microdialysis

    Författare :Madelene Sandqvist; Göteborgs universitet; []
    Nyckelord :;

    Sammanfattning : Type 2 diabetes is characterized by a combination of insulin resistance and an impaired insulin secretion. Theprevalence of the disease has taken epidemic proportions, and it is therefore of great concern to characterize itspathophysiology, as well as to identify individuals with increased risk for the disease, enabling to take measuresfor prevention and cure. LÄS MER

  7. 10. Lipid Metabolism and Insulin Signalling in Adipocytes : enhanced autophagy in type 2 diabetes

    Författare :Anita Öst; Peter Strålfors; Johanna Gustavsson Dahlberg; Anna Krook; Linköpings universitet; []
    Nyckelord :MEDICINE; MEDICIN;

    Sammanfattning : Energy storage in the adipose tissue, to an extent leading to obesity, is associated with local as well assystemic insulin resistance. When insulin-producing beta-cells in the pancreas gradually fail tocompensate, plasma levels of glucose rise and overt type 2 diabetes is diagnosed. LÄS MER