Sökning: "IRS-1"

Visar resultat 11 - 15 av 28 avhandlingar innehållade ordet IRS-1.

1. 11. Role of Cell-cell Interactions and Palmitate on β-cells Function

   Författare :Azazul Islam Chowdhury; Peter Bergsten; Gunilla Westermark; Peter Jones; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Metabolism; PI3K; Pseudoislets; Human islets; SOCS; PIAS; Biology with specialization in Molecular Biology; Biologi med inriktning mot molekylärbiologi;

   Sammanfattning : The islets of Langerhans secrets insulin in response to fluctuations of blood glucose level and efficient secretion requires extensive intra-islet communication. Secretory failure from islets is one of the hallmark in progression of type 2 diabetes. LÄS MER

3. 12. Glucose and lipid metabolism in insulin resistance : an experimental study in fat cells

   Författare :Jonas Burén; Umeå universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Public health; adipocyte; insulin resistance; type 2 diabetes; insulin signalling; glucose uptake; insulin; glucose; dexamethasone; insulin receptor substrate; protein kinase B; GLUT4; lipoprotein lipase; Folkhälsomedicin; Public health medicine research areas; Folkhälsomedicinska forskningsområden; medicin; Medicine;

   Sammanfattning : Type 2 diabetes is usually caused by a combination of pancreatic β-cell failure and insulin resistance in target tissues like liver, muscle and fat. Insulin resistance is characterised by an impaired effect of insulin to reduce hepatic glucose production and to promote glucose uptake in peripheral tissues. LÄS MER

4. 13. Role of MAP Kinases in the Life and Death of Beta-cells

   Författare :Natalia Makeeva; Nils Welsh; Godfried Roomans; Thomas Mandrup-Poulsen; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cell biology; diabetes; beta-cell; p38 MAPK; nitric oxide; apoptosis; Cellbiologi; Cell biology; Cellbiologi;

   Sammanfattning : The development of diabetes mellitus depends on the balance between beta-cell proliferation and death. As mitogen-activated protein kinases (MAPK) may control this balance, the aim of this study was to investigate the events leading to MAPK activation in beta-cells and the consequences of these events. LÄS MER

5. 14. Caveolae in insulin signalling in human and rat adipocytes

   Författare :Margareta Karlsson; Bengt Jergil; Linköpings universitet; []
   Nyckelord :MEDICINE; MEDICIN;

   Sammanfattning : The pancreatic hormone insulin is a key hormone in maintenance of metabolic homeostasis but it also exerts control on gene expression and cell growth. This thesis presents results on fhe role of caveolae in insulin signalling in human and rat adipocytes. LÄS MER

7. 15. Regulation of intracellular signaling events that modulate insulin action

   Författare :Silvia Gogg; Göteborgs universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; insulin; insulin resistance; EGF; Gab 1; insulin receptor substrate; PI3-kinase; ; Thiazolidinediones; PPARã; insulin signaling; glucose transport; adipose tissue; â-cell.;

   Sammanfattning : Insulin regulates several mechanisms of fundamental importance to the body involving glucose, fat andprotein metabolism. Insulin resistance in skeletal muscle, liver and adipose tissue promotes an increaseddemand for insulin secretion. LÄS MER