Sökning: "IRS-1"

Visar resultat 16 - 20 av 28 avhandlingar innehållade ordet IRS-1.

  1. 16. Mechanisms of insulin signaling and the role of caveolae

    Författare :Santiago Parpal; Pam Fredman; Linköpings universitet; []
    Nyckelord :MEDICINE; MEDICIN;

    Sammanfattning : Insulin regulates metabolic as well as mitogenic processes in target cells, involving a large number of mediators of signal transduction. In its role as a growth factor, insulin stimulates cell growth, in a process we demonstrate requires the participation of the Raf-1 kinase. LÄS MER

  3. 17. Insulin signaling and glucose transport in insulin resistant human skeletal muscle

    Författare :Håkan K R Karlsson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Skeletal muscle; insulin resistance; type 2 diabetes; glucose transport; insulin signaling; first-degree relatives; AS160; SelS; rosiglitazone treatment;

    Sammanfattning : Insulin resistance in skeletal muscle is a hallmark feature of Type 2 diabetes mellitus. The overall aim of this thesis was to investigate downstream intermediates in the insulin signaling pathway in an attempt to characterize the molecular mechanism of skeletal muscle insulin resistance in Type 2 diabetes. LÄS MER

  4. 18. Interplay between hormones, nutrients and adipose depots in the regulation of insulin sensitivity : an experimental study in rat and human adipocytes

    Författare :Magdalena Lundgren; Jan Eriksson; Jonas Burén; Eva Degerman; Umeå universitet; []
    Nyckelord :LANTBRUKSVETENSKAPER; AGRICULTURAL SCIENCES; adipose tissue; cAMP; glucocorticoids; glucose; insulin; insulin resistance; lipolysis; subcutaneous fat; type 2 diabetes; visceral fat; Medicine; Medicin;

    Sammanfattning : Obesity and specifically central obesity is related to insulin resistance, type 2 diabetes and other components of the so-called metabolic syndrome. The aim of this study was to elucidate the interplay between hormones, nutrients and adipose depots in normal and insulin-resistant fat cell metabolism. LÄS MER

  5. 19. Molecular dissection of pathways regulating glucose and lipid metabolism using siRNA

    Författare :Anna Rune; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Type 2 diabetes is a complex chronic disease that is associated with skeletal muscle insulin resistance. The aim of this thesis is to investigate pathways regulating glucose and lipid metabolism in human skeletal muscle. Whole body metabolism differs between men and women. LÄS MER

  7. 20. Role of protein-tyrosine phospatases in insulin and glucagon secretion in pancreatic islets of healthy rats and spontaneously diabetic GK rats

    Författare :Jie Chen; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Protein-tyrosine phosphatase; insulin; glucagon; vanadate; type 2 diabetes; pancreatic islets;

    Sammanfattning : Both insulin and glucagon secretion from pancreatic beta- and alpha-cells, respectively, are regulated by nutrients such as glucose and amino acids. In addition, the mechanisms leading to exocytosis of hormones are influenced by kinases and phosphatases that phosphorylate and dephosphorylate regulatory proteins respectively. LÄS MER