Sökning: "IGF-1R"

Visar resultat 11 - 15 av 44 avhandlingar innehållade ordet IGF-1R.

1. 11. Biased signalling at the IGF-1R : pitfalls and potential of the GRK/beta-arrestin system in cancer therapeutics

   Författare :Caitrin Crudden; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Embedded into the boundary between the living machinery and the external space, plasma membrane receptors allow cells to perceive their environment and elicit appropriate responses. Two of the largest classes of receptors are the G protein-coupled receptors (GPCRs) and receptor tyrosine kinases (RTKs). LÄS MER

3. 12. Regulation of insulin-like growth factor-1 receptor expression and signaling

   Författare :Radu Vasilcanu; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :IGF-1R; â-arrestins; MDM2; ubiquitination; internalization;

   Sammanfattning : Insulin-like growth factor-1 receptor (IGF-1R), a member of the insulin receptor tyrosine kinase family is a broadly expressed transmembrane receptor that plays a key role in malignant cell growth. IGF-1R transmits information provided by extracellular stimuli into intracellular signaling pathways resulting in the subsequent regulation of various effector systems. LÄS MER

4. 13. Targeting insulin-like growth factor-1 receptor in cancer

   Författare :Ada Girnita; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :IGF1; IGF-1R; MDM2; p53; PPP; Tamoxifen; tyrosine kinase inhibitors; ubiquitin;

   Sammanfattning : Cancer is a multi-step process where the accumulation of several genetic and epigenetic alterations drives the transformation of a normal cell to a malignant cell, skipping the normal control of defense, repair and apoptosis. During the selection process towards a malignant phenotype, the transforming cells make use of normal (physiological) extracellular signaling pathways to create growth advantage over normal cells. LÄS MER

5. 14. Growth factor pathways in human cancer : functional and therapeutic implications

   Författare :Leonard Girnita; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :IGF-1R; growth factors; p53; fusion protein; tyrosine kinase inhibitors; ubiquitin;

   Sammanfattning : The multi-step development of tumors involves numerous changes at genomic level such as oncogene activation, loss of function of tumor suppressor genes and translocations resulting in fusion genes that encodes for chimeric proteins with tumorigenic functions etc. However, in the selection leading to cancer in somatic tissues it is likely that the cancer cells make use of the normal extracellular signaling for proliferation and/or anti-apoptosis to create growth advantage over the normal cells. LÄS MER

7. 15. Tumor progression in melanocytic lesions : biological and diagnostic implications

   Författare :Lena Kanter-Lewensohn; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :melanocytic tumors; MIB-1; Bcl-2; IGF-1R. p27; cyclins; cdks and Tamoxifen;

   Sammanfattning : Cutaneous malignant melanoma has an annual incidence of 5% in Sweden, with about 1500 cases diagnosed yearly. In routine histopathology there are diagnostic difficulties in the analysis of pigmented lesions. LÄS MER