Sökning: "Hydroxylation"

Visar resultat 6 - 10 av 79 avhandlingar innehållade ordet Hydroxylation.

  1. 6. Fatty acid hydroxylation in rat kidney and liver microsomes

    Författare :Åke Ellin; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES;

    Sammanfattning : .... LÄS MER

  3. 7. Formation of active metabolites by demethylation and hydroxylation of tricyclic antidepressants in man

    Författare :Britt Mellström; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; PHARMACY; FARMACI;

    Sammanfattning : .... LÄS MER

  4. 8. Quinine metabolism in man : emphasis on the 3-hydroxylation as a biomarker reaction for the activity of CYP3A4

    Författare :Rajaa A Mirghani; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Quinine is one of the cinchona alkaloids and used in the treatment of severe forms of malaria. Formation of 3-hydroxyquinine is catalysed by cytochrome P-450 3A4 (CYP3A4), which is the enzyme involved in the metabolism of about 50% of all drugs in clinical use. LÄS MER

  5. 9. Cytochrome P450 Enzymes in the Metabolism of Vitamin D3

    Författare :Fardin Hosseinpour; Leif Bertilsson; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutical biosciences; Farmaceutisk biovetenskap; Biopharmacy; Biofarmaci; Biochemistry; biokemi;

    Sammanfattning : A cytochrome P450 enzyme in pig kidney that catalyzes the hydroxylations of vitamin D3 and C27-sterols was cloned. DNA sequence analysis of the cDNA revealed that the enzyme belongs to the CYP27 family. The recombinant kidney CYP27A enzyme catalyzed the 25-hydroxylation of vitamin D3 and the 27-oxygenation of C27-sterols. LÄS MER

  7. 10. Enzymes in different pathways of bile acid biosynthesis

    Författare :Catrin Furster; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutical biosciences; Farmaceutisk biovetenskap; Biopharmacy; Biofarmaci; Biochemistry; biokemi;

    Sammanfattning : Enzymes catalyzing side chain hydroxylations and dehydrogenation/isomerization in different pathways of bile acid biosynthesis were studied.Pig liver mitochondrial sterol 27-hydroxylase (CYP27A) was found to catalyze 24- and 25-hydroxylation of cholesterol in addition to the known 27-hydroxylation. LÄS MER