Sökning: "Histone methylation"

Visar resultat 11 - 15 av 73 avhandlingar innehållade orden Histone methylation.

  1. 11. Genetic and Epigenetic Characterisation of Breast Tumours

    Författare :Karolina Holm; Bröstcancer-genetik; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Breast cancer; PIK3CA; PTEN; PI3K pathway; CCND1; microarrays; molecular subtypes; DNA methylation; EZH2; H3K27me3; PRC2; histone modification;

    Sammanfattning : Breast tumours harbour a large amount of genetic and epigenetic alterations, which are associated with e.g. tumour aggressiveness, prognosis, and response to therapy. LÄS MER

  3. 12. Expression and function of Suppressor of zeste 12 in Drosophila melanogaster

    Författare :Sa Chen; Åsa Rasmuson-Lestander; Jan Larsson; Mattias Mannervik; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Epigenetics; histone; polycomb; Drosophila; Suppressor of zeste 12; Genetics; Genetik; genetik; Genetics;

    Sammanfattning : The development of animals and plants needs a higher order of regulation of gene expression to maintain proper cell state. The mechanisms that control what, when and where a gene should (or should not) be expressed are essential for correct organism development. LÄS MER

  4. 13. Aberrant DNA methylation in acute myeloid leukemia

    Författare :Ying Qu; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : DNA methylation is an important epigenetic mechanism that influences development and cancer by regulating gene transcription. Aberrant DNA methylation is a feature of cancer including acute myeloid leukemia (AML). LÄS MER

  5. 14. Studies of histone modification systems in Schizosaccharomyces pombe

    Författare :Carolina Bonilla; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The genetic information in every cell is carried in the DNA. In eukaryotes the DNA is wrapped twice around proteins called histones forming a repeating unit called the nucleosome, in fibers known as chromatin. Nucleosomes are folded into higher order structures forming the chromosomes. LÄS MER

  7. 15. Genome-wide patterns of histone modifications in fission yeast

    Författare :Indranil Sinha; Karl Ekwall; Karin Dahlman-Wright; Södertörns högskola; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES;

    Sammanfattning : DNA is wrapped almost two times around a group of proteins called histones to form a chromosomal structure known as the nucleosome. Both DNA and histones can be modified with different chemical tags by several enzymes to activate or suppress a particular gene or group of genes. Histones can be covalently modified at several places. LÄS MER