Sökning: "E-cadherin"

Visar resultat 16 - 20 av 59 avhandlingar innehållade ordet E-cadherin.

  1. 16. Study of the Proliferation, Function and Death of Insulin-Producing Beta-Cells in vitro: Role of the Transcription Factor ZBED6

    Författare :Xuan Wang; Nils Welsh; Nils Billestrup; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; ZBED6; Pancreatic beta-cell; Proliferation; Insulin secretion; Apoptosis; Adhesion; Medical Science; Medicinsk vetenskap;

    Sammanfattning : A thorough understanding of beta-cell proliferation, function, death and regeneration under normal condition as well as in the progression of diabetes is crucial to the conquest of this disease. The work presented in this thesis aimed to investigate the expression and role of a novel transcription factor, Zinc finger BED domain-containing protein 6 (ZBED6), in beta-cells. LÄS MER

  3. 17. Different genetic pathways involved in colorectal cancer

    Författare :Sima Salahshor; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Colorectal cancer (CRC) is one of the three leading causes of cancer mortality worldwide with an incidence of approximately one million cases and a mortality of 500 000 annually. Identification of different pathways involved in tumorigenesis of both familial and sporadic colorectal cancer may led to a major breakthrough in the prevention of this potentially curable disease. LÄS MER

  4. 18. Novel roles of ErbB3 receptor tyrosine kinase in vesicular trafficking

    Författare :Ana Rosa Saez-Ibañez; Ingvar Ferby; Carl-Henrik Heldin; Johanna Ivaska; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; ErbB3; Integrin; GGA3; Rabaptin5; PKD; Ack1; endocytic recycling; exosome; Biology with specialization in Molecular Cell Biology; Biologi med inriktning mot molekylär cellbiologi;

    Sammanfattning : ErbB3 is a catalytically impaired receptor tyrosine kinase (RTK) from the EGFR family. Upon ligand binding, ErbB3 forms heterodimers with other members of the family and triggers phosphorylation cascades that promote crucial cellular functions as proliferation, differentiation and survival. LÄS MER

  5. 19. Rho-GTPases in Morphogenesis and Differentiation of the Developing Pancreas

    Författare :Thomas Greiner; Stamcellscentrum (SCC); []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; insulin; diabetes; beta cell; cell adhesion; migration; delamination; morphogenesis; tubulogenesis; pancreas; Cdc42; Rho-GTPase; Rac1;

    Sammanfattning : Branched tubular networks constitute the basic structure of many organs to increase surface area and to transport fluids and gases. Glandular organs such as the pancreas arise from multilayered epithelium, which undergoes de novo lumen formation and extensive remodeling and branching. LÄS MER

  7. 20. Epstein-Barr virus encoded deconjugases and AmotL2 in control of cell topology

    Författare :Sebastian Hildebrand; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : EPSTEIN-BARR VIRUS ENCODED DECONJUGASES: The post-translational conjugation or deconjugation of proteins by ubiquitin (Ub) or ubiquitin-like molecules (UbLs: e.g. SUMO, NEDD8, ISG15) has emerged as a major regulatory mechanism of various cellular activities. Viruses have developed mechanisms to exploit those pathways for their own benefit. LÄS MER