Sökning: "Cellular reprogramming"

Visar resultat 11 - 15 av 38 avhandlingar innehållade orden Cellular reprogramming.

  1. 11. Interaction of the genome maintenance proteins of oncogeneic herpesviruses with cellular chromatin

    Författare :Muhammad Nouman Mughal; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The Epstein-Barr virus (EBV) nuclear antigen (EBNA)-1 is the only viral protein expressed in all virus-infected cells and EBV-associated malignancies. Similar to the genome maintenance proteins (GMPs) of other gamma-herpesviruses, EBNA1 binds to both viral and cellular DNA and controls the replication and transcription of the viral genome. LÄS MER

  3. 12. The transcriptomic landscape of Epstein-Barr virus associated tumors at cellular and single-molecule level

    Författare :Yarong Tian; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Epstein-Barr virus; carcinogenesis; RPMS1; miRNA; single-cell sequencing; immune evasion;

    Sammanfattning : Epstein-Barr virus (EBV) was the first oncovirus found in humans. Almost all adults worldwide are asymptomatic carriers of EBV. The latent EBV-infection malignifies in approximately 200,000 individuals each year. LÄS MER

  4. 13. Coiled coil cytoskeleton in cell architecture and osmotic stress response in Streptomyces

    Författare :Katsuya Fuchino; Molekylär cellbiologi; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Coiled coil protein; Streptomyces coelicolor; polar growth; osmotic-stress response; turgor;

    Sammanfattning : Coiled coil proteins emerge as important determinants of bacterial cellular organization. Several such proteins display properties characteristic to metazoan intermediate filament (IF) proteins, and are therefore designated bacterial IF-like proteins. LÄS MER

  5. 14. Generating new models to study propagation and pathology of alpha-synuclein in Parkinson's disease and multiple system atrophy

    Författare :Staffan Holmqvist; Stamcellslaboratoriet för sjukdomsmodellering i det centrala nervsystemet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : Synucleinopthies are neurodegenerative diseases characterised by the formation of α-synuclein-rich intracellular inclusions in neurons and glia. Traditionally, animalmodels and immortalized cell lines have been used to investigate why and how theseinclusions form, and how they impact on cellular function. LÄS MER

  7. 15. Deciphering microglia plasticity in glioma

    Författare :Dalel Saidi; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Microglia are the innate immune cells of the brain. One of the main characteristics of microglia is its extremely plasticity, which is necessary for them to deal with changing circumstances. Activation of microglia can contribute to contrasting effects by either proinflammatory, anti-inflammatory, or tumor-supportive phenotypes. LÄS MER