Sökning: "Canonical WNT pathway"

Visar resultat 16 - 20 av 28 avhandlingar innehållade orden Canonical WNT pathway.

  1. 16. Stem cells for cardiac regeneration

    Författare :Ivana Bulatović; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Recent studies have demonstrated a turnover of cardiomyocytes throughout the adult life. Whether this regenerative potential is due to proliferation and differentiation of resident stem cells or to the dedifferentiation of adult cardiomyocytes remains unclear. LÄS MER

  3. 17. Bone Development and the Nervous System

    Författare :Gregor Sisask; Olof Nilsson; Anders Bjurholm; Kenneth B Jonsson; André Stark; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cell biology; Cellbiologi;

    Sammanfattning : Innervation of bone influence bone modeling, growth and remodeling. Pro-inflammatory cytokines released after tissue trauma are recognized as neurotrophic factors as well as factors influencing bone formation. The Wnt signaling pathway, essential for cell migration during embryogenesis is found to influence bone formation during fracture healing. LÄS MER

  4. 18. Regulation of MYC transcription in 3D : implications for tumor development

    Författare :Ilias Tzelepis; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : This thesis uncovers how chromatin organization conspires with nuclear architecture and environmental stimuli in order to regulate gene expression in disease and particular, in cancer. In Paper I, we have unraveled a mechanism of oncogenesis, previously unknown in humans, and widely known as gene gating. LÄS MER

  5. 19. New potential targets in medulloblastoma therapy : studies on cellular mechanisms and mediators

    Författare :Ninib Baryawno; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Medulloblastoma is an embryonal tumour that mainly affects children. It is the most common malignant brain tumour in children and accounts for 15% of all childhood brain tumours. It most often presents in the cerebellum and is considered to be a disorder of normal development. LÄS MER

  7. 20. The Foxf2 gene in development and disease

    Författare :Azadeh Reyahi; Göteborgs universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Foxf2; Pericyte; brain development; stroke;

    Sammanfattning : The Foxf2 gene in development and disease Azadeh Reyahi Department of Chemistry and Molecular Biology, University of Gothenburg, Box 462, SE 405 30, Göteborg, Sweden Abstract In this thesis I present our recent data on the involvement and the mechanism of action of the forkhead transcription factor Foxf2 in development of the brain microvasculature, formation of the blood-brain barrier, control of the intestinal stem cell niche, and fusion of the secondary palate. The potential clinical signifi- cance of these findings is strengthened by a correlation between Foxf2 expres- sion and intestinal adenoma formation, and by association between genetic vari- ants in human FOXF2 and incident stroke. LÄS MER