Sökning: "CTLA-4"

Visar resultat 36 - 40 av 54 avhandlingar innehållade ordet CTLA-4.

  1. 36. Checkpoint inhibitor-induced adverse events in the CNS - T-cell characteristics and biomarkers

    Författare :Sara Bjursten; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Melanoma; Immune checkpoint inhibition; Immune related adverse events to the CNS; T cells;

    Sammanfattning : Immune checkpoint inhibitors (ICI) activate T cells to kill cancer cells by blocking inhibitory receptors PD-1 (nivolumab; nivo) or CTLA-4 (ipilimumab; ipi). Activated T cells can also attack any healthy organ, causing unpredictable immune related adverse events (irAE). The risk of irAE is highest when treating with ipi and nivo simultaneously. LÄS MER

  3. 37. The blind spot : inflammatory pathways and specific antigens in clinical phenotypes of pulmonary sarcoidosis

    Författare :Ylva Kaiser; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Sarcoidosis is a granulomatous multisystem disorder of unknown aetiology, primarily manifesting in the lungs. The disease appears in two forms, which are mainly distinguished based on clinical criteria; Löfgren's syndrome (LS) presents with acute onset, usually fever, active inflammation and characteristic symptoms such as bilateral hilar lymphadenopathy (BHL), erythema nodosum and/or ankle arthritis, but is also associated with spontaneous resolution and a good prognosis. LÄS MER

  4. 38. Promoting healing of skin and mucosa by immunomodulation using CXCL12 producing lactic acid bacteria : From bench to bedside

    Författare :Emelie Öhnstedt; Mia Phillipson; Neil Forbes; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; L.reuteri; wound healing; non-healing wounds; ILP100; colitis; immunotherapy;

    Sammanfattning : Immunotherapies direct the immune system to respond in a certain way, such as to fight cancer or to dampen inflammation. In this thesis, a new immunotherapy, ILP100, is developed using a technology that allows for local production of short-lived immunoregulatory proteins that previously have been undruggable. LÄS MER

  5. 39. Transcriptional control of CD4+ T lymphocytes

    Författare :Peter C J Janson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The immune system can respond to various types of pathogens such as bacteria, viruses, tumors and parasites. The ability to provide protection against different types of pathogens partly relies on development of alternative T effector cells with separate effector functions. LÄS MER

  7. 40. Tolerance Mechanisms in Collagen-Induced Arthritis an Animal Model of Rheumatoid Arthritis

    Författare :Alexandra Treschow; Immunologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Skeleton; Tolerance; Regulation; IFN-beta; Macrophages; Immunology; serology; transplantation; Immunologi; serologi; Arthritis; Collage; rheumatology locomotion; muscle system; Skelett; muskelsystem; reumatologi;

    Sammanfattning : Collagen-induced arthritis (CIA) is one of the most commonly used animal models for Rheumatoid arthritis (RA). CIA is induced in susceptible mouse strains after immunization with heterologous type II collagen (CII). In mice of the H-2q haplotype rat CII (rCII) is used whereas in mice of the H-2r haplotype bovine CII is utilized. LÄS MER