Sökning: "Anaplastic large cell lymphoma"

Visar resultat 1 - 5 av 13 avhandlingar innehållade orden Anaplastic large cell lymphoma.

1. 1. Anaplastic Lymphoma Kinase mutations and downstream signalling

   Författare :Christina Schönherr; Ruth H Palmer; Aristidis Moustakas; Umeå universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Anaplastic Lymphoma Kinase; oncogene; RTK; neuroblastoma; crizotinib; NVP-TAE684; gain-of-function; MYCN; transcription factor; small GTPase; Rap1; C3G; PC12 cells; neurite outgrowth; molecular cell biology; molekylär cellbiologi;

   Sammanfattning : The oncogene Anaplastic Lymphoma Kinase (ALK) is a Receptor Tyrosine Kinase (RTK) and was initially discovered as the fusion protein NPM (nucleophosmin)-ALK in a subset of Anaplastic Large Cell Lymphomas (ALCL). Since then more fusion proteins have been identified in a variety of cancers. LÄS MER

3. 2. Investigating the function of Anaplastic Lymphoma Kinase

   Författare :Emma Vernersson Lindahl; Bengt Hallberg; Ruth Palmer; Göran Roos; Carina Hellberg; Umeå universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; ALK; nervous system; knockout; development; Jelly-Belly; Pathology; Patologi;

   Sammanfattning : Anaplastic Lymphoma Kinase (ALK) was discovered in 1994, as a chromosomal translocation, t(2;5)(p23;q35), often seen in Anaplastic Large Cell Lymphomas (ALCL). Since then ALK has been extensively studied in this disease as well as in different model organisms. LÄS MER

4. 3. Anaplastic lymphoma kinase activity, a therapeutic target, suppresses neuroblastoma cell differentiation

   Författare :Joachim T. Siaw; Göteborgs universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neuroblastoma; ALK; 11q.; DLG2; SP1; differentiation; crizotinib; ceritinib; brigatinib;

   Sammanfattning : Neuroblastoma (NB) is the most common extracranial pediatric solid malignancy caused by the failed differentiation of precursor cells of the developing sympathetic nervous system. NB accounts for about 15% of childhood cancer-related deaths. LÄS MER

5. 4. Epidemiological and clinical aspects of T-cell lymphoma

   Författare :Henrik Cederleuf; Medicinsk onkologi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; population-based; peripheral T-cell lymphoma; Anaplastic large cell lymphoma; angioimmunoblastic; elderly; ASCT; comorbidity; prognostic factors; follow-up; limited stage; etoposide; CHOP; overall survival; radiotherapy;

   Sammanfattning : T-cell lymphoma (TCL) is a rare group of malignancies and one of the important aims in this thesis has been to broaden the general knowledge of TCL with descriptive patient data. Main focus has been to examine prognosticfactors for overall survival (OS) and progression-free survival (PFS), and to evaluate different treatment approaches and follow-up (FU) after treatment. LÄS MER

7. 5. Mechanistic Implications and Characterization of Anaplastic Lymphoma Kinase (ALK) mutations in Neuroblastoma

   Författare :Damini Chand; Bengt Hallberg; Christer Larsson; Umeå universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; neuroblastoma; ALK; crizotinib; receptor tyrosine kinase; molekylärbiologi; Molecular Biology;

   Sammanfattning : Anaplastic lymphoma kinase (ALK) is a receptor tyrosine kinase that was first reported as a fusion partner of nucleophosmin in Anaplastic large cell lymphoma in 1994. ALK is involved in myriad of cancers including neuroblastoma which is the most common extracranial solid tumor affecting young children. LÄS MER