Sökning: "APS 1"
Visar resultat 21 - 25 av 31 avhandlingar innehållade orden APS 1.
21. Pituitary autoantibodies in endocrine disorders
Sammanfattning : Autoimmune endocrine disorders are characterised by the development of autoantibodies to specific autoantigens in the target organs. Lymphocytic hypophysitis (LyH) is a disease characterised by inflammation of the pituitary gland, often resulting in hypopituitarism. The aetiology of LyH is considered to be autoimmune. LÄS MER
22. Molecular Targets in Autoimmune Polyendocrine Syndrome Type1 and Their Clinical Implications
Sammanfattning : Autoimmune diseases occur when the immune system attacks and destroys healthy body tissue. Autoimmunity is known to cause a wide range of disorders, and is suspected to be responsible for many more. Most autoimmune disorders are chronic and cause severe morbidity for the patients, and are also costly for society. LÄS MER
23. Studies of clinical and haemostatic features associated with antiphospholipid antibodies
Sammanfattning : Background: Antiphospholipid antibodies (aPL) are associated with a heterogeneous range of clinical conditions with predisposition for thrombosis, pregnancy morbidity and other autoimmune disorders, most frequently systemic lupus erythematosus (SLE). Both the clinical manifestations themselves and their treatment may be harmful to the affected individuals and aPL testing is still controversial. LÄS MER
24. Model diseases for studies of autoimmunity
Sammanfattning : The events triggering autoimmune diseases are to large extent unknown and model diseases are an important tool in studies aiming to elucidate molecular mechanisms in autoimmunity. Autoimmune Addison’s disease (AAD) is a rare disease characterized by autoimmune destruction of adrenal glands and most patients with AAD have autoantibodies against the enzyme 21‑hydroxylase in the adrenal cortex. LÄS MER
25. Cysteine biosynthesis in Mycobacterium tuberculosis as potential drug target
Sammanfattning : The bacterium Mycobacterium tuberculosis is the underlying cause of tuberculosis, one of the most devastating infectious diseases, causing 1.4 million deaths in 2015. LÄS MER