Sökning: "tumor evolution"

Visar resultat 1 - 5 av 50 avhandlingar innehållade orden tumor evolution.

  1. 1. Cancer Evolution under Chemotherapy Treatment

    Författare :Kaname Uno; Cancercellers evolution; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; ovarian cancer; Wilms tumor; chemotherapy resistance; ascites; spheroids; diffuse anaplasia;

    Sammanfattning : Background: Chemotherapy resistance is a critical issue in oncology, being responsible for the majority of deaths in modern cancer care. My PhD work has focused on two cancer types where such drug resistance is a major clinical issue: epithelial ovarian cancer (EOC) and Wilms tumor (WT). LÄS MER

  3. 2. Inter and intra-tumor models of somatic evolution in cancer

    Författare :Mohammadreza Mohaghegh Neyshabouri; Jens Lagergren; Ben Raphael; KTH; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Cancer progression models; MCMC; Tillämpad matematik och beräkningsmatematik; Applied and Computational Mathematics;

    Sammanfattning : Cancer is a disease caused by the accumulation of somatic mutations in an evolutionary process. Mutations in so-called cancer driver genes provide the harboring cells with particular selective advantages and result in cancer progression. LÄS MER

  4. 3. Massively Parallel Sequencing of Gene Fusion-Associated Sarcomas

    Författare :Jakob Hofvander; Avdelningen för klinisk genetik; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Sarcomas; Gene fusion; tumor evolution; clonal heterogeneity; RNA-seq; WES; SNP-array;

    Sammanfattning : .... LÄS MER

  5. 4. Affibody molecules targeting the epidermal growth factor receptor for tumor imaging applications

    Författare :Mikaela Friedman; Stefan Ståhl; Fredrik Nilsson; James S. Huston; KTH; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Affibody; affinity maturation; phage display selection; EGFR; molecular imaging; protein engineering; tumor targeting; Bioengineering; Bioteknik;

    Sammanfattning : Tumor targeting and molecular imaging of protein markers specific for or overexpressed in tumors can add useful information in deciding upon treatment and assessing the response to treatment for a cancer patient. The epidermal growth factor receptor (EGFR) is one such tumor-associated receptor, which expression is abnormal or upregulated in various cancers and associated with a poor patient prognosis. LÄS MER

  7. 5. Staphylococcal surface display in directed evolution

    Författare :Nina Kronqvist; Stefan Ståhl; Mats A. A. Persson; KTH; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; affibody; combinatorial library; directed evoluation; Gram-positive bacteria. protein engineering; Bioengineering; Bioteknik;

    Sammanfattning : Engineered affinity proteins have together with naturally derived antibodies becomeindispensable tools in many areas of life-science and with the increasing number ofapplications, the need for high-throughput methods for generation of such different affinityproteins is evident. Today, combinatorial protein engineering is the most successful strategy toisolate novel non-immunoglobulin affinity proteins. LÄS MER