Sökning: "preclinical modeling"
Visar resultat 1 - 5 av 13 avhandlingar innehållade orden preclinical modeling.
1. Preclinical tumor-immune modeling : For the identification of immunomodulatory drugs
Sammanfattning : For a long time, the field of cancer research was dominated by a tumor cell-centric view. That, however, changed once it became recognized that medical cancer treatment is largely influenced by the combined effect exerted on both cancer and immune cells. LÄS MER
2. Data-driven modeling of combination therapy in oncology
Sammanfattning : This thesis contains two manuscripts: Tumor Static Concentration Curves in Combination Therapy and Extending the Tumor Static Concentration Curve to Exposure - A Combination Therapy Example with Radiation Therapy. There is also an introductory chapter presenting some basic facts necessary to understand the appended manuscripts. LÄS MER
3. Pharmacokinetic-Pharmacodynamic modeling and prediction of antibiotic effects
Sammanfattning : Problems of emerging antibiotic resistance are becoming a serious threat worldwide, and at the same time, the interest to develop new antimicrobials has declined. There is consequently a need for efficient methods to develop new treatments that minimize the risk of resistance development and that are effective on infections caused by resistant strains. LÄS MER
4. Nonlinear Mixed Effects Modeling of Combination Therapies in Oncology
Sammanfattning : It has been shown that simultaneous administration of two or more anticancer agents can have a beneficial effect on cancer patients. This type of treatment is called combination therapy and is nowadays commonly used in the fight against cancer. LÄS MER
5. Utilizing Biopolymers in 3D Tumor Modeling and Tumor Diagnosis
Sammanfattning : Cancer represents a significant global public health challenge and ranks as the second mostcommon cause of death in the United States. The onset of cancer entails an initial phasewhere cells lose their polarity and disconnect from the normal basement membrane, allowingthem to form distinct three-dimensional (3D) configurations that interact with adjacent cellsand the surrounding microenvironment. LÄS MER