Sökning: "antibiotics"

Visar resultat 1 - 5 av 239 avhandlingar innehållade ordet antibiotics.

  1. 1. A tale of two antibiotics Fusidic acid and Viomycin

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Mikael Holm; Uppsala universitet.; [2016]
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Protein Synthesis; Antibiotics; Fusidic acid; Viomycin; Translocation; Accuracy; Molecular Biotechnology; Molekylär bioteknik;

    Sammanfattning : Antibiotics that target the bacterial ribosome make up about half of all clinically used antibiotics. We have studied two ribosome targeting drugs: Fusidic acid and Viomycin. Fusidic acid inhibits bacterial protein synthesis by binding to elongation factor G (EF-G) on the ribosome, thereby inhibiting translocation of the bacterial ribosome. LÄS MER

  2. 2. Resistant pneumococci and use of antibiotics

    Detta är en avhandling från Department of Community Medicine, Malmö University Hospital

    Författare :Eva Melander; Lunds universitet.; Lund University.; Lunds universitet.; Lund University.; [2000]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Mikrobiologi; bakteriologi; mycology; virology; streptococcus pneumoniae; Antibiotics; drug resistance; bacteriology; Microbiology; virologi; mykologi;

    Sammanfattning : Pneumococcal resistance to antibiotics has become a worldwide problem. The rapid increase in frequency seems to be caused by intercontinental spread of a few resistant clones. Resistance to antibiotics in pneumococci has reduced the therapeutic arsenal for common respiratory tract infections as well as for invasive infections. LÄS MER

  3. 3. Antibiotics and infusion phlebitis. Clinical and experimental studies

    Detta är en avhandling från Peter Lanbeck, Department of Infectious Diseases, Malmo University Hospital, SE-205 02 Malmö, Sweden

    Författare :Peter Lanbeck; Lunds universitet.; Lund University.; [2003]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; HUVEC; Infections; endothelium vascular; Infektioner; ICAM-1; 3H-thymidine incorporation; cloxacillin; dicloxacillin; phlebitis epidemiology; Antibiotics; phlebitis chemically induced;

    Sammanfattning : Intravenous administration of antibiotics is often followed by infusion phlebitis. In this condition are vessel irritation, inflammation and sometimes superficial thrombosis included. In this thesis, the risk for infusion phlebitis for various antibiotics has been evaluated in a clinical study in 550 patients. LÄS MER

  4. 4. Pharmacokinetic and Pharmacodynamic Modeling of Antibiotics and Bacterial Drug Resistance

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Ami Fazlin Syed Mohamed; Uppsala universitet.; [2013]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmacometrics; pharmacokinetics; pharmacodynamics; modeling; antibiotics; resistance; combination; Gram-negative bacteria; gentamicin; colistin; meropenem; newborn infants; critically ill patients; Infektionssjukdomar; Infectious Diseases; Farmaceutisk vetenskap; Pharmaceutical Science;

    Sammanfattning : Exposure to antibiotics is an important factor influencing the development of bacterial resistance.  In an era where very few new antibiotics are being developed, a strategy for the development of optimal dosing regimen and combination treatment that reduces the rate of resistance development and overcome existing resistance is of utmost importance. LÄS MER

  5. 5. Monitoring anti-infectives and antibiotic resistance genes with focus on analytical method development, effects of antibiotics and national perspectives

    Detta är en avhandling från Umeå : Umeå University

    Författare :Ghazanfar Ali Khan; Umeå universitet.; [2012]
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; method development; on-line solid phase extraction liquid chromatography mass spectrometry SPE LC-MS MS ; antibiotics; anti-infectives; constructed wetlands CWs ; denatured gradient gel electrophoresis DGGE ; percentage removal efficiency PRE ; shannon index; antibiotic resistance genes ARGs ; real-time polymerase chain reaction RT-PCR ; drug formulation facilities DFF ; wastewater; epidemiology; pandemic; influenza; compliance;

    Sammanfattning : Antibiotics are biologically active and are globally used in humans and animal medicine for treatment and in sub-therapeutic amounts as growth promoters in animal husbandry, aquaculture and agriculture. After excretion, inappropriate disposal and discharge from drug production facilities they enter into water bodies either as intact drugs, metabolites or transformed products. LÄS MER