Sökning: "Marcus Baaz"

Hittade 2 avhandlingar innehållade orden Marcus Baaz.

  1. 1. Nonlinear Mixed Effects Modeling of Combination Therapies in Oncology

    Författare :Marcus Baaz; Stiftelsen Fraunhofer-Chalmers Centrum för Industrimatematik (FCC); []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmacol- ogy; Radiation Therapy; Oncology; Mathematical Modeling; Combination Therapy; Nonlinear Mixed Effects;

    Sammanfattning : It has been shown that simultaneous administration of two or more anticancer agents can have a beneficial effect on cancer patients. This type of treatment is called combination therapy and is nowadays commonly used in the fight against cancer. LÄS MER

  3. 2. Pharmacometrics for Combination Therapy in Oncology Within and Across Species Variability in Time Series and Time-to-event Data

    Författare :Marcus Baaz; Chalmers tekniska högskola; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Mathematical Modeling; Pharmacometrics; Nonlinear Mixed Effects; Oncology; Combination Therapy; Radiation Therapy;

    Sammanfattning : Mathematical modeling is an integral part of the drug development process. Models are developed to describe tumor dynamics or drug concentration to answer questions such as: What concentration is required to reach the desirable treatment outcome? What drug dose and frequency should a drug prescription specify to achieve this concentration? Models are also used for simulation, reducing the need to perform additional animal trials. LÄS MER