Sökning: "organometallic synthesis"

Visar resultat 21 - 25 av 31 avhandlingar innehållade orden organometallic synthesis.

1. 21. METAL CARBONYL MEDIATED REACTIONS - APPLICATIONS IN THE SYNTHESIS OF POTENTIAL GALECTIN INHIBITORS

   Författare :Nuria Parera Pera; Chalmers tekniska högskola; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES;

   Sammanfattning : AbstractThis work reports the development of an asymmetric version of the Nicholas reaction using monodentate phosphoramidites as ligands, which enables asymmetric synthesis from racemic starting material. In addition, we describe the application of metal carbonyl mediated reactions, such as the Pauson-Khand reaction (PKR) and reactions involving cationic iron carbonyl dienyl complexes, for the synthesis of potential galectin inhibitors, implicated in human inflammatory responses and various pathologies. LÄS MER

3. 22. Metallocene based peptidomimetics and chiral catalysts

   Författare :Suzana Maricic; Centrum för analys och syntes; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Organic chemistry; Organisk kemi; asymmetric catalysis.; metallocene based amino alcohols; one-pot macrocyclisation; cyclic peptides; Organometallic substance P and Leu 5 -enkephalin; conformational analysis;

   Sammanfattning : Several optically active organometallic Phe-AAn-Phe peptidomimetics and macrocyclic Phe-(Phe)n peptides have been synthesized by either intra- or intermolecular peptide bond formation of the corresponding bis(amino acid) derivatives. The key bis(amino acid) derivatives were available from an improved multi-step synthetic route, utilising Horner-Wadswort-Emmons olefination of organometallic aldehydes with phosphonylglycine reagents, enantioselective hydrogenation of didehydro amino acids and classical solution and/or solid phase peptide synthesis methodology. LÄS MER

4. 23. Development of Multi-Component Reactions using Catalytically Generated Allyl Metal Reagents

   Författare :Nicklas Selander; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Organic Chemistry; Organic chemistry; Organisk kemi;

   Sammanfattning : This licentiate thesis is based on the development of catalytic reactions for the synthesis and application of organometallic reagents. By use of palladium pincer-complex catalysts, we have developed an efficient procedure for the synthesis of allylboronates starting from allylic alcohols. LÄS MER

5. 24. Development of New Synthetic Routes to Organoboronates by Catalytic Allylic Substitution and C-H bond Functionalization

   Författare :Vilhelm Olsson; Kálmán Szabó; Gary A. Molander; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Palladium; Iridium; Boron; Catalysis; Organic chemistry; Organisk kemi; organisk kemi; Organic Chemistry;

   Sammanfattning : This thesis describes the development of new catalytic methods for the synthesis and application of organometallic reagents, mainly focusing on allylboronic acid derivatives. Thus, palladium pincer-complex catalysis has been applied for extending the scope of palladiumcatalyzed borylation reactions in the synthesis of regio- and stereodefined functionalized allylboronic acid derivatives. LÄS MER

7. 25. Radical Cyclization Approaches to Pyrrolidines

   Författare :Magnus Beşev; Troels Skrydstrup; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Organic chemistry; Radical cyclization; diastereselectivity; pyrrolidine; pyrroline; thiazoline; aziridine; Organisk kemi; Organic chemistry; Organisk kemi; organisk kemi; Organic Chemistry;

   Sammanfattning : Five-membered rings are readily prepared by 5-exo-trig radical cyclization. This thesis is concerned with novel methodology for pyrrolidine synthesis. We have synthesised selenium containing radical precursors from aziridines and α-phenylseleno ketones, and cyclized them to 2,4- and 3,4-disubstituted pyrrolidines. LÄS MER