Sökning: "extracellular matrix"

Visar resultat 1 - 5 av 555 avhandlingar innehållade orden extracellular matrix.

  1. 1. Extracellular Matrix Based Materials for Tissue Engineering

    Författare :Cecilia Aulin; Jöns Hilborn; Tim Bowden; Laura Creemers; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Extracellular matrix; collagen synthesis; bioreactor; cell culture; bone morphogenetic protein-2; noggin; hyaluronan; cartilage; Medical technology; Medicinsk teknik; Molecular biology; Molekylärbiologi; Orthopaedics; Ortopedi; Transplantation surgery; Transplantationskirurgi; Biomaterials; Biomaterial; Morphology; cell biology; pathology; Morfologi; cellbiologi; patologi; Cell and molecular biology; Cell- och molekylärbiologi; Polymer chemistry; Polymerkemi; Materials chemistry; Materialkemi; cellforskning; Cell Research; materialvetenskap; Materials Science; medicinsk cellbiologi; Medical Cell Biology; ortopedi; Orthopaedics;

    Sammanfattning : The extracellular matrix is (ECM) is a network of large, structural proteins and polysaccharides, important for cellular behavior, tissue development and maintenance. Present thesis describes work exploring ECM as scaffolds for tissue engineering by manipulating cells cultured in vitro or by influencing ECM expression in vivo. LÄS MER

  3. 2. About hyaluronan in the hypertrophic heart : studies on coordinated regulation of extracellular matrix signalling

    Författare :Urban Hellman; Anders Waldenström; Stellan Mörner; Anna Engström-Laurent; Lena Jonasson; Umeå universitet; []
    Nyckelord :hyaluronan; hyaluronan synthases; gene expression; extracellular matrix; cardiac hypertrophy; rat wistar; male ; cardiomyocytes; growth factors; fibroblasts; microvesicles; exosomes; MEDICINE; MEDICIN; Medicine; medicin;

    Sammanfattning : Background. Myocardial hypertrophy is a risk factor for cardiovascular morbidity and mortality. Independent of underlying disease, the cardiac muscle strives in different ways to compensate for an increased workload. This remodelling of the heart includes changes in the extracellular matrix which will affect systolic and diastolic cardiac function. LÄS MER

  4. 3. Studies on extracellular matrix proteins in vascular disease

    Författare :Åsa Ström; Kärlväggsbiologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Kardiovaskulära systemet; Cardiovascular system; smooth muscle cells; osteopontin; extracellular matrix; atherosclerosis;

    Sammanfattning : The composition of the vascular extracellular matrix (ECM) is altered during remodeling conditions such as atherosclerosis. The changed ECM regulates events that are important for the progression of disease including smooth muscle cell (SMC) behaviour and collagen fiber formation. LÄS MER

  5. 4. Fluid biomarkers of extracellular matrix remodelling across neurological diseases

    Författare :Karolina Minta; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Alzheimer’s disease; biomarker; extracellular matrix; idiopathic normal pressure hydrocephalus; immunoassay; mass spectrometry; radiation-induced brain injury; traumatic brain injury; vascular dementia;

    Sammanfattning : Neurological diseases constitute a major health and socioeconomic issue. Despite an enormous amount of research going on globally, the prevalence and mortality of neurological disorders are still rising. LÄS MER

  7. 5. Structure and Interactions of the Extracellular Matrix Protein PRELP

    Författare :Eva Bengtsson; Institutionen för experimentell medicinsk vetenskap; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; reumatologi; muskelsystem; Skelett; extracellular matrix; PRELP; heparin; heparan sulfate; perlecan; collagen; cell-binding; Skeleton; rheumatology locomotion; muscle system; Biochemistry; Metabolism; Biokemi;

    Sammanfattning : This thesis describes the structure and interactions of a novel extracellular matrix protein - PRELP (proline arginine-rich end leucine-rich repeat protein). The amino acid sequence of PRELP showed that it belonged to the leucine-rich repeat (LRR) protein family in connective tissues. LÄS MER