Sökning: "pyrrolidine"
Visar resultat 1 - 5 av 26 avhandlingar innehållade ordet pyrrolidine.
1. Radical Cyclization Approaches to Pyrrolidines
Sammanfattning : Five-membered rings are readily prepared by 5-exo-trig radical cyclization. This thesis is concerned with novel methodology for pyrrolidine synthesis. We have synthesised selenium containing radical precursors from aziridines and α-phenylseleno ketones, and cyclized them to 2,4- and 3,4-disubstituted pyrrolidines. LÄS MER
2. Synthesis of N-Containing Compounds: Development of Methodology and its Application in Total Synthesis
Sammanfattning : This thesis aims to develop new synthetic methods and explore the possibilities to apply it in the total synthesis of natural products.Chapter 2 deals with a mild procedure for the synthesis of a-keto amides by a-oxidation of the corresponding aketo amines mediated by pyrrolidine and TEMPO. LÄS MER
3. Construction of Five-Membered Heterocyclic Compounds via Radical Cyclization
Sammanfattning : This thesis describes how radical cyclization chemistry can be applied for the construction of heterocyclic compounds.In the first part, a series of electron deficient α-phenylselenenylalkenes were prepared via a PhSeCl-addition/HCl-elimination sequence. LÄS MER
4. Synthesis of Tetrahydrofuran and Pyrrolidine Derivatives Utilising Radical Reactions : Organochalcogenides in Reductive, Carbonylative and Group-Transfer Cyclisation
Sammanfattning : This thesis describes free-radical reactions for the construction of tetrahydrofuran and pyrrolidine derivatives. The studies are concerned with (i) diastereoselectivity in radical cyclisation, (ii) construction of tetrahydrofuran-3-ones and pyrrolidin-3-ones via radical carbonylation/cyclisation and (iii) synthesis of tetrahydrofuran derivatives via group-transfer cyclisation of organochalcogen compounds. LÄS MER
5. 1. Asymmetric aldol and alkylation reactions using pyrrolidine-based chiral auxiliaries 2. Syntheses of pine sawfly pheromone precursors and structurally related compounds
Sammanfattning : This thesis describes the syntheses of the 1-propionylatedauxiliaries (S)-(− )-2-(pyrrolidin-2-yl)propan-2-ol and (S)-(− )-2-(1-methoxy-1-methylethyl)pyrrolidine andtheir use in asymmetric aldol and alkylation reactions. Thesynthesis of 1-propionylated (2S,4R) 2-{4-[(tert-butyldimethylsilyl)oxy]pyrrolidin-2-yl}propan-2-olis also described. LÄS MER