Sökning: "cyclic peptides"

Visar resultat 1 - 5 av 50 avhandlingar innehållade orden cyclic peptides.

1. 1. Studies in solid phase peptide synthesis and self-assembly of cyclic peptides

   Författare :Katri Rosenthal-Aizman; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Peptides; cyclic; Peptider;

   Sammanfattning : .... LÄS MER

3. 2. Cyclic peptides as biological tools : Applications for diagnosis and therapeutics in rheumatoid arthritis and COVID-19

   Författare :Camilla Eriksson; Ulf Göransson; Sunithi Gunasekera; Christian Becker; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Scaffold peptides; peptide grafting; rheumatoid arthritis; SARS-CoV-2; autoantibodies; peptide synthesis; pharmacognosy;

   Sammanfattning : The overall aims of the projects included in this thesis were to design, synthesize and evaluate cyclic peptide scaffolds grafted with biological epitopes for their ability to bind antibodies in rheumatoid arthritis and COVID-19 sera. One of the main outcomes of this thesis was the observation that scaffold peptides grafted with target epitopes efficiently neutralized anti-citrullinated protein autoantibodies (ACPA) from rheumatoid arthritis patients. LÄS MER

4. 3. Development of methods for the solid-phase synthesis of backbone modified peptides and small organic molecules

   Författare :Kalle Kaljuste; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Neurochemistry; Peptides; cyclic;

   Sammanfattning : .... LÄS MER

5. 4. Conformational Stability!? : Synthesis and Conformational Studies of Unnatural Backbone Modified Peptides

   Författare :Anna S. Norgren; Per I. Arvidsson; Norbert Sewald; Uppsala universitet; []
   Nyckelord :Organic chemistry; Conformational investigations; β-peptides; glycosylation; biomolecular recognition; cyclic β³-peptides; cyclic mixed α β²-peptides; β-peptoids; Organisk kemi;

   Sammanfattning : The beauty of the wide functionality of proteins and peptides in Nature is determined by their ability to adopt three-dimensional structures. This thesis describes artificial molecules developed to mimic secondary structures similar to those found crucial for biological activities. LÄS MER

7. 5. Development of antimicrobial peptides : Methodological aspects, design, synthesis and evaluation of a new class of antimicrobial peptides

   Författare :Marie Danielsson; Anders Undén; Maria Kempe; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; neurokemi med molekylär neurobiologi; Neurochemistry with Molecular Neurobiology;

   Sammanfattning : A new protective group for the indole nitrogen of the amino acid tryptophan, the Boc-sarcosinoyl-sarcosinolyl (Boc-Sar-Sar) is described. This protective group shows good stability to the reaction conditions used in solid phase peptide synthesis and can be incorporated into the peptide as Fmoc-Trp(Boc-Sar-Sar)-OH. LÄS MER