Sökning: "liquid biopsy"
Visar resultat 1 - 5 av 15 avhandlingar innehållade orden liquid biopsy.
1. Circulating platelets : a novel liquid biopsy source for cancer diagnostics and therapy stratification
Sammanfattning : As conventional tissue biopsies have several drawbacks, much effort has been directed toward the development of minimal-invasive liquid biopsy platforms for detecting and profiling cancer.Platelets are the second most abundant cells in blood and have very versatile functions both in physiological and pathophysiological conditions. LÄS MER
2. Ultrasensitive DNA sequencing using liquid biopsies enables precision medicine
Sammanfattning : Liquid biopsies are minimally invasive and allow repetitive sampling of body fluids. Analysis of cell-free tumor DNA in liquid biopsies can be used as a biomarker for cancer. However, in most clinically relevant liquid biopsies, cell-free DNA is present at low concentrations, contains minute tumor allele frequencies, and is highly fragmented. LÄS MER
3. Next generation molecular diagnostics using ultrasensitive sequencing
Sammanfattning : Massively parallel sequencing enables the exploration of the genetic heterogeneity within microbial, viral and tumor cell populations. Detecting circulating tumor DNA in blood and other body fluids has the potential to revolutionize molecular diagnostics. LÄS MER
4. Ultrasensitive Molecular Monitoring of Breast Cancer and Acute Myeloid Leukemia
Sammanfattning : Cancer is the common name to a group of biologically diverse malignant neoplastic diseases. Approximately 18 million people are diagnosed with cancer annually and 8.8 million patients die from it. Tumorigenesis and progression of cancer are driven by alterations in the cancer cell genome. LÄS MER
5. Liquid biopsies in pediatric oncology : towards clinical implementation
Sammanfattning : During the last few years, liquid biopsies based on cell-free DNA (cfDNA) have become approved for clinical use in several areas of adult oncology. Due to the minimally invasive nature of this procedure, liquid biopsies could serve many purposes in childhood oncology as well. LÄS MER